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CHIR 99021 (CT99021)

CHIR-99021 HCl is a synthetic small molecule inhibitor of GSK3 kinase, with IC50 of 10 and 6.7nM for GSK3α and GSK3β, respectively. Has >500-fold selectivity for GSK3 over closely related CDC2 and ERK2 kinases. Functions as a WNT activator.

Catalog No. Size Price Quantity
92-1116 2 mg $289.00

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Description
CHIR 99021 (CT99021)
Compound Type
Inhibitor
Storage
≤ -20°C
Source
Synthetic
Cells were plated in a 384-well plate and incubated overnight at 37°C/5% CO2 to allow the cells to attach and grow. Cells were then stimulated with a control compound, using the assay conditions described below. Following stimulation, signal was detected using the PathHunter Detection Kit according to the recommended protocol.