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Geldanamycin

Geldanamycin is an antibiotic and potent antagonist of the heath shock protein 90 (Hsp90) protein (KD=1.2uM), binding its ATP site and inhibiting its chaperone activity. Induces degradation of mutated proteins v-Src, Bcr-Abl, Raf, p53, and steroid receptors in tumor cells selectively over non-mutated counterparts via Hsp90 inhibition. Affects multiple cellular processes, including gene expression, cell proliferation, apoptosis, and angiogenesis.

Catalog No. Size Price Quantity
92-1235 1 mg $626.00

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Description
Geldanamycin
Compound Type
Agonist
Storage
-20°C
Source
Synthetic