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PD0325901

PD0325901 is a synthetic orally active MEK1 and MEK2 inhibitor (Ki=1.1 and 0.79, respectively) that research shows inhibits the growth of melanoma cell lines in-vitro and in-vivo. Also inhibits production of VEGF proangiogenic cytokines, and suppresses the phosphorylation of ERK and the RAS/RAF/MEK/ERK signaling pathway, which is frequently active in tumors.

Catalog No. Size Price Quantity
92-1184 5 mg $152.00

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Description
PD0325901
Compound Type
Agonist
Storage
≤ -20◦C
Source
Synthetic
Cells were plated in a 384-well plate and incubated overnight at 37°C/5% CO2 to allow the cells to attach and grow. Cells were then stimulated with a control compound, using the assay conditions described below. Following treatment, signal was detected using the InCELL Hunter Detection Kit according to the recommended protocol.