Application Notes

Cytokines play a crucial role in immune responses and have become important drug targets for treating inflammatory and autoimmune diseases.

SHP2 (Src-homology 2 domain-containing phosphatase 2) is a protein tyrosine phosphatase encoded by the human PTPN11 gene.SHP2 is a key…

Histone modifications are essential in eukaryotic gene expression and regulation, and are driven by histone writer, eraser, and reader proteins.…

As more is learned about the intricacies of GPCR signaling, the harder it becomes to accurately describe ligand activity using…

Here we show how PathHunter GPCR Internalization assays can be used to differentiate between strongly internalizing and weakly internalizing agonist…

An Application Note Assessing the Regulation of Mast Cell Function and its Implications in Safety Pharmacology. MrgprX2 antagonism promotes fresh…

The development of antibody-based therapeutics to target the killing of tumor cells has revolutionized the space of immuno-oncology and the…

As more is learned about the intricacies of GPCR signaling, the harder it becomes to accurately describe ligand activity using…