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As key mediators of immune responses, cytokines have emerged as major drug targets for inflammatory and autoimmune diseases. A significant…
Read MoreAgonistic Antibodies and the Role of Checkpoint Receptors in Immune Function
Read MoreMost therapeutic antibodies have a Fab’ region that binds the antigen, and an Fc region which binds to and activates…
Read MoreLigand bias is the ability of compounds to exert differential signal transduction responses on activation of a GPCR. This is…
Read MoreArrestins are ubiquitously expressed and function in the activation of GPCRs, desensitization of most 7-transmembrane receptors (7-TMs), and regulation of…
Read MoreTranslocation and Trafficking of Membrane Proteins
Read MoreMost GPCRs are pleiotropically coupled to multiple signaling pathways in cells and the availability of functional assays to separately measure…
Read MoreThe development of new medicines for treating diseases and new chemical probes for elucidating biological function continues to rely on…
Read MorePresenting a compelling narrative on the pharmacological characterization of the MRGX2 gene. Dr. Brown emphasized the receptor’s importance as a…
Read MoreWhether you’re looking to screen a library of drug candidates for binding to a particular target protein, checking drug cell…
Read MoreCell-based assays are useful for understanding cellular pathways; characterizing targets and their function; identifying, screening, and optimizing ligands or drugs…
Read MoreBiological activity of a biotherapeutic is a Critical Quality Attribute (CQA), which needs to be accurately measured by an appropriate…
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