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Vasopressin receptor 1A (V1A) - AVPR1A

Target Class GPCR FamilyVasopressin and Oxytocin
SpeciesHuman   
Background
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]

Cell Background
U2OS
Readout
Calcium
Method
Detect calcium mobilization using DiscoverX Calcium No WashPLUS
Agonist/Ligand
[Arg8]-Vasopressin
Agonist Effect (Activation)
water retention in body; increase BP; decrease HR; myocardial fibrosis; cardiac hypertrophy; hyponatraemia
Antagonist Effect (Inhibition)
insufficient information
Ref.
Bowes et. al. 2012
Cells are plated in a 384-well plate and incubated overnight at 37°C/5% CO2 to allow the cells to attach and grow. Cells are then stimulated with a control agonist. Following stimulation, calcium mobilization is detected using the Calcium No WashPLUS detection kit.
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