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5-hydroxytryptamine receptor 2A (5HT2A) - HTR2A

Target Class GPCR Family5-Hydroxytryptamine
SpeciesHuman   
Background
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Cell Background
U2OS
Readout
Calcium
Method
Detect calcium mobilization using DiscoverX Calcium No WashPLUS
Agonist/Ligand
5-HT
Agonist Effect (Activation)
smoth muscle contraction; platelet aggregation; potential memory impairments; hallucinations; schizophrenia; serotonin syndrome
Antagonist Effect (Inhibition)
insufficient information
Ref.
Bowes et. al. 2012
Cells are plated in a 384-well plate and incubated overnight at 37°C/5% CO2 to allow the cells to attach and grow. Cells are then stimulated with a control agonist. Following stimulation, calcium mobilization is detected using the Calcium No WashPLUS detection kit.
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