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Monoamine oxidase A - MAOA

Target Class Non-Kinase Enzymes FamilyMonoamine oxidase
SpeciesHuman   
Background
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

Protein Source
Human(recombinant): Microsomes from baculovirus infected insect cells
Readout
Enzymatic activity
Method
Detect conversion of kynuramine to 4-hydroquinoline using fluorescent readout
Substrate
Kynuramine
Agonist Effect (Activation)
insufficient information
Antagonist Effect (Inhibition)
increase BP when combined with amines; DDI potential; dizziness; sleep disturbances; nausea
Ref.
Bowes et. al. 2012
AntagonistIC50(nM)
Clorgyline1
R-(-)-Deprenyl 4600
Enzyme and test compound are preincubated for 15 minutes at 37 C before substrate addition. Reaction is initiated by addition of kynuramine and incubated at 37 C for 30 minutes. Reaction is terminated by addition of NaOH. Determine amount of 4-hydroquioline formed through spectrofluorimetric readout at 380 nm.
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