Extensive 3′ alternative splicing of the mu opioid receptor gene OPRM1 creates multiple C-terminal splice variants. However, their behavioral relevance…
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Cell-based assays are useful for understanding cellular pathways; characterizing targets and their function; identifying, screening, and optimizing ligands or drugs…
Read MoreKinase inhibitors often potently inhibit several off-target kinases in biochemical assays. Unfortunately, the relevance of these off-target interactions in a…
Watch NowThe clinical success of an ever-increasing array of biologics has led to the development of a wide spectrum of immunomodulatory…
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Cytokines play a crucial role in immune responses and have become important drug targets for treating inflammatory and autoimmune diseases.…
Read MoreG-protein-coupled receptors (GPCRs) have varying and diverse physiological roles, transmitting signals from a range of stimuli, including light, chemicals, peptides,…
Read MoreG-protein-coupled receptors (GPCRs) have varying and diverse physiological roles, transmitting signals from a range of stimuli, including light, chemicals, peptides,…
Read MoreIt is well established that ligand binding can protect proteins from thermal denaturation in a cellular milieu; however, the broad…
Watch NowHere we will describe InCELL Pulse™, which uses DiscoverX’s Enzyme Fragment Complementation (EFC) technology to overcome these limitations of current…
Watch NowCell-based reporter gene assays are a well-established screening modality for developing drugs that target diverse signaling pathways.
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