v-raf murine sarcoma viral oncogene homolog B1 (BRAF(V600E))

Target Class
Kinase
Family
TKL
Official Symbol
BRAF
Entrez Gene ID
673
Species
Human
Accession Number
NP_004324.2
Alias Names
94 kDa B-raf protein; B-RAF1; B-Raf proto-oncogene serine/threonine-protein kinase (p94); BRAF1; NS7; RAFB1; murine sarcoma viral (v-raf) oncogene homolog B1; p94; proto-oncogene B-Raf; serine/threonine-protein kinase B-raf; v-raf murine sarcoma viral oncogene homolog B1
Background
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008]
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Related Group Members: TKL
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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