Targets / Kinase / KIT(V559D)

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT(V559D))

Target Class
Kinase
Family
TK
Official Symbol
KIT
Entrez Gene ID
3815
Species
Human
Accession Number
NP_000213.1
Alias Names
C-Kit; CD117; PBT; SCFR; mast/stem cell growth factor receptor Kit; p145 c-kit; piebald trait; piebald trait protein; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; soluble KIT variant 1; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Background
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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Related Group Members: TK
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