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leucine-rich repeat kinase 2 (LRRK2(G2019S))

Target Class
Kinase
Family
TKL
Official Symbol
LRRK2
Entrez Gene ID
120892
Species
Human
Accession Number
NP_940980.3
Alias Names
AURA17; DARDARIN; PARK8; Parkinson disease (autosomal dominant) 8; RIPK7; ROCO2; augmented in rheumatoid arthritis 17; leucine-rich repeat kinase 2; leucine-rich repeat serine/threonine-protein kinase 2
Background
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
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Related Group Members: TKL
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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