Targets / Kinase / PIK3CA(E542K)

phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA(E542K))

Target Class
Kinase
Family
Lipid
Official Symbol
PIK3CA
Entrez Gene ID
5290
Species
Human
Accession Number
NP_006209.2
Alias Names
PI3-kinase p110 subunit alpha; PI3K; PI3K-alpha; p110-alpha; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform; phosphoinositide-3-kinase, catalytic, alpha polypeptide; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein kinase PIK3CA
Background
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008]
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