Targets / Kinase / TGFBR1/TGFBR2/ENG
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Transforming growth factor, beta receptor 1

Target Class
KINASE
Family
Ser/Thr Kinase
Official Symbol
TGFBR1
Species
Human
Accession Number
NM_004612
Alias Names
AAT5; ACVRLK4; ALK-5; ALK5; LDS1A; LDS2A; MSSE; SKR4; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFR-1; activin A receptor type II-like kinase; 53kD; activin A receptor type II-like kinase; 53kDa; activin A receptor type II-like protein kinase of 53kD; activin receptor-like kinase 5; serine/threonine-protein kinase receptor R4; tbetaR-I; transforming growth factor beta receptor I; transforming growth factor; beta receptor 1; transforming growth factor; beta receptor I (activin A receptor type II-like kinase; 53kD); transforming growth factor-beta receptor type I
Background
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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Solution Portfolio

Related Group Members: Ser/Thr Kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Cell Lines
Assay Measures Background Species Cell Line
TGFBR1/TGFBR2 Dimerization U2OS Human 93-0889C3
Dimerization U2OS Human 93-1122C3
Ready to Use eXpress Kits
Assay Measures Background Species Assay Kit
TGFBR1/TGFBR2 Dimerization U2OS Human 93-0889E3CP5M
TGFBR1/TGFBR2 Dimerization U2OS Human 93-0889E3CP5L
LeadHunter Screening & Profiling Services
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan