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[EUROFINS GPCR SYMPOSIUM 2022] Ligand Characterization of Mas-Related GPCR-X2 via Cell-Based Assays: Implications in Safety Liability Tests

[EUROFINS GPCR SYMPOSIUM 2022] Ligand Characterization of Mas-Related GPCR-X2 via Cell-Based Assays: Implications in Safety Liability Tests
Version:
21344

File Name/Number:
EUROFINS GPCR SYMPOSIUM

Year:
2022

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Mast cells are principal players in IgE-, and more recently, non-IgE-mediated anaphylactoid reactions or pseudo-allergic Adverse Drug Reactions (ADR). A wide range of ligands can activate mast cells owing to their multiple receptor expression profiles, and their characterization hence warrants closer study, especially into their safety pharmacological roles.