[PEGS 2018] Driving Robust and Reproducible ADCC and T Cell Redirection with Single Donor KILR® CD16 Effector Cells

[PEGS 2018] Driving Robust and Reproducible ADCC and T Cell Redirection with Single Donor KILR® CD16 Effector Cells
Version:
20803

File Name/Number:
PEGS 2018

Year:
2018

Success of ADCC assays is highly dependent on the quality of effector cells used. However, human primary cells (such as PBMCs or NK cells) suffer from inter-individual variability, while NK cell lines engineered to overexpress CD16, often show high background lysis in susceptible cell models, and high functional variability under different culture conditions.