Publications
Showing 1–12 of 36 results
Discovery and development of new molecules directed against validated pain targets is required to advance the treatment of pain disorders.…
Read MoreStriatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific enzyme that regulates the signaling molecules that control synaptic plasticity and neuronal…
Read MoreThe MAS-related Gq protein-coupled receptor X4 (MRGPRX4) is poorly investigated. MRGPRX4 has been proposed to be involved in pain transmission,…
Read MoreType 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a…
Read MoreType 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a…
Read MoreSystemic therapy of advanced hepatocellular carcinoma (HCC) with the small molecule multi-kinase inhibitor sorafenib is associated with large inter-individual pharmacokinetic…
Read MoreA series of substituted indoles were examined as selective inhibitors of tropomyosin-related kinase receptor A (TrkA), a therapeutic target for…
Read MorePhosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are emerging as attractive therapeutic targets in diseases, such as cancer, immunological disorders, and neurodegeneration, owing…
Read MoreBrain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), have emerged as key regulators of brain plasticity and…
Read MoreCurrent therapies for chronic pain can have insufficient efficacy and lead to side effects, necessitating research of novel targets against…
Read MoreStrong genetic data link the Tyrosine kinase receptor B (TrkB) and its major endogenous ligand brain-derived neurotrophic factor (BDNF) to…
Read MoreG-protein-coupled receptors (GPCRs) have varying and diverse physiological roles, transmitting signals from a range of stimuli, including light, chemicals, peptides,…
Read More