Search results: “ATM”

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Publications Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1.8 with a Unique Mechanism of Action

Discovery and development of new molecules directed against validated pain targets is required to advance the treatment of pain disorders.…

Publications Design, synthesis and SAR of substituted indoles as selective TrkA inhibitors.

A series of substituted indoles were examined as selective inhibitors of tropomyosin-related kinase receptor A (TrkA), a therapeutic target for…

Publications Sorafenib activity and disposition in liver cancer does not depend on organic cation transporter 1 (OCT1).

Systemic therapy of advanced hepatocellular carcinoma (HCC) with the small molecule multi-kinase inhibitor sorafenib is associated with large inter-individual pharmacokinetic…

Webinars Accelerating COVID-19 Drug Discovery: Qualified Cell-Based Assays for Proinflammatory Cytokines

COVID-19 has been declared a global pandemic by WHO. The disease is transmitted when the SARS-CoV-2 virus infects the respiratory…

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Scientific Posters Accelerate Drug Development of GLP-1 & -2 Receptor Analogs with Ready-to-Use Cell-Based Assays

There is an increasing need to generate therapeutics targeting metabolic and gastrointestinal diseases to address the global burden of metabolic…

Scientific Posters CAR-T Cell Screening in Tumor Spheroids Using Corning Spheroid Microplates

Chimeric antigen receptor (CAR)-T cells, which are engineered to recognize target cell surface antigens expressed on tumor cells, have shown…

Scientific Posters Development and Evaluation of a Novel Bioassay for Denosumab Activity

Denosumab (Prolia®) is a fully human sequence derived monoclonal antibody used for the treatment of osteoporosis in menopausal women via…

Presentations [PEGS 2021] Accelerating Development of Therapeutic Interventions for COVID-19

Gaurav Agrawal, Ph.D. Scientific Development Manager Abstract Millions of deaths worldwide have been attributed to COVID-19, caused by the SARS-CoV-2…

Application Notes Ligand Characterization of Mas-Related GPCR-X2 via Cell-Based Assays: Assessing the Regulation of Mast Cell Function and Implications in Safety Pharmacology

An Application Note Assessing the Regulation of Mast Cell Function and its Implications in Safety Pharmacology. MrgprX2 antagonism promotes fresh…

Brochures & Flyers Expedite Cancer Drug Discovery & Development

Functional Cell-Based Assays, Cell Lines, & Proteins for Cancer Research Improved or novel small molecule or biologic therapeutics for cancer…