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Blogs & Articles Advancing Therapeutics Targeting Cytokines

As key mediators of immune responses, cytokines have emerged as major drug targets for inflammatory and autoimmune diseases. A significant…

Scientific Posters Advancing Therapeutics Targeting Inflammatory Cytokines with Functional Cell-based Assays

Case studies on the use of cell-based assays that monitor receptor dimerization and signaling reporter activation targeting IL-12, IL-23, IL-15,…

Presentations Advancing Therapeutics Targeting Cytokines with Functional Cell-based Assays

Jennifer Lin-Jones, Ph.D., Associate Director of Assay Development R&D Department, Eurofins DiscoverX

Webinars Advancing Therapeutics Targeting Cytokines with Functional Cell-based Assays

Watch this webinar to discover functional cell-based assays for characterizing novel therapeutics & biosimilars targeting cytokines in inflammation & oncology.

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Publications Detection of Cellular Target Engagement for Small-Molecule Modulators of Striatal-Enriched Protein Tyrosine Phosphatase (STEP)

Striatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific enzyme that regulates the signaling molecules that control synaptic plasticity and neuronal…

Scientific Posters Implementing MOA-Reflective ADCC Assays using Ready-to-Use KILR Target and Effector Cells from Screening to Lot Release

The clinical success of an ever-increasing array of biologics has led to the development of a wide spectrum of immunomodulatory…

Publications InCELL Target Engagement: A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells, Exemplified Using SMYD3 and IDO1

A persistent problem in early small-molecule drug discovery is the frequent lack of rank-order correlation between biochemical potencies derived from…

Publications A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)

A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)

Publications A cellular target engagement assay for the characterization of SHP2 (PTPN11) phosphatase inhibitors

The non-receptor protein tyrosine phosphatase (PTP) SHP2 is encoded by the proto-oncogene PTPN11 and is a ubiquitously expressed key regulator…

Publications Measurement of β-Arrestin Recruitment for GPCR Targets.

β-Arrestins are ubiquitously expressed in all cell types, and function in the desensitization of G- protein coupled receptors (GPCRs), the…

Publications Comparison of four in vitro cytotoxicity assays for assessing the potency of CD3-bispecific antibodies redirecting T cells to kill tumor target cells

Evaluation of cytotoxicity is a critical step in the selection of CD3-bispecific antibodies (BsAbs) for cancer immunotherapy.

Qualification Data Sargramostim Bioassay Kit Qualification Data

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