Search results: “IL-2”

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Publications Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2

Regulatory T cells (Tregs) are indispensable for maintaining self-tolerance by suppressing conventional T cells. On the other hand, Tregs promote…

Blogs & Articles Advancing Therapeutics Targeting Cytokines

As key mediators of immune responses, cytokines have emerged as major drug targets for inflammatory and autoimmune diseases. A significant…

Scientific Posters Advancing Therapeutics Targeting Inflammatory Cytokines with Functional Cell-based Assays

Case studies on the use of cell-based assays that monitor receptor dimerization and signaling reporter activation targeting IL-12, IL-23, IL-15,…

Scientific Posters Comprehensive & Fit-For-Purpose Solutions to Enable Drug Development for Cytokine Targets

Interleukins are known for their involvement in functioning of both the adaptive and innate immune systems. Interleukins direct immune cells…

Scientific Posters Measuring Receptor Dimerization To Create Functional Cell-Based Assays for ~85% of the Interleukin Receptor Family

Ligand-induced receptor dimerization is the first functional step in receptor activation, representing the most proximal, functional read-out for receptor activation.…

Presentations [Cytokines Summit 2022] Enabling Cytokine Therapeutic Development with Qualified, Functional Cell-Based Assays

Gaurav Agrawal, Ph.D.Scientific Development Manager Discover how cell-based assays and translational services accelerate cytokine-based immunotherapeutic development from early discovery to…