G-protein-coupled receptors (GPCRs) have varying and diverse physiological roles, transmitting signals from a range of stimuli, including light, chemicals, peptides,…
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Ligand-induced receptor dimerization is the first functional step in receptor activation, representing the most proximal, functional read-out for receptor activation.…
Read MoreLigand-induced receptor dimerization is the first functional step in receptor activation, representing the most proximal, functional read-out for receptor activation.…
Read MoreLigand-induced receptor dimerization is the first functional step in receptor activation, representing the most proximal, functional read-out for receptor activation.…
Read MoreAs key mediators of immune responses, cytokines have emerged as major drug targets for inflammatory and autoimmune diseases. A significant…
Read MoreCheckpoint blockade antibodies are established cancer therapeutics. However, in recent years, agonistic antibodies have emerged as therapeutics not only for…
Read MoreCase studies on the use of cell-based assays that monitor receptor dimerization and signaling reporter activation targeting IL-12, IL-23, IL-15,…
Read MoreBrain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), have emerged as key regulators of brain plasticity and…
Read MorePhosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are emerging as attractive therapeutic targets in diseases, such as cancer, immunological disorders, and neurodegeneration, owing…
Read MoreAs newer, cutting-edge therapeutic technologies emerge, an increasing need for rapid and reliable screening tools follows.
Read MoreThe COVID-19 pandemic has left us racing against time for remediation. As a result, we have witnessed hundreds of therapeutic…
Read MoreCytokines and their receptors have emerged as major drug targets for inflammatory and autoimmune diseases, allergies, and, more recently, in…
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