Cytokines play a crucial role in immune responses and have become important drug targets for treating inflammatory and autoimmune diseases.
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The MAS-related Gq protein-coupled receptor X4 (MRGPRX4) is poorly investigated. MRGPRX4 has been proposed to be involved in pain transmission,…
Read MoreMast cells are principal players in IgE-, and more recently, non-IgE-mediated anaphylactoid reactions or pseudo-allergic Adverse Drug Reactions (ADR). A…
Read MoreAn Application Note Assessing the Regulation of Mast Cell Function and its Implications in Safety Pharmacology. MrgprX2 antagonism promotes fresh…
Read MoreA series of substituted indoles were examined as selective inhibitors of tropomyosin-related kinase receptor A (TrkA), a therapeutic target for…
Read MoreBrain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), have emerged as key regulators of brain plasticity and…
Read MoreMast cells play key roles in allergy, anaphylaxis/anaphylactoid reactions, and defense against pathogens/toxins. These cells contain cytoplasmic granules with a…
Read MoreA persistent problem in early small-molecule drug discovery is the frequent lack of rank-order correlation between biochemical potencies derived from…
Read MoreLigand bias is the ability of compounds to exert differential signal transduction responses on activation of a GPCR. This is…
Read MoreReady-to-Use qualified PathHunter® checkpoint bioassays are fit-forpurpose for potency testing for implementation in downstream development phases and Lot release of…
Read MoreThe complex interactions between tumor cells and the host immune system are only beginning to be understood, however it is…
Watch NowDiscoveRx has developed a panel of over 120 characterized GPCR cell lines that monitor receptor activity using interaction with human…
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