Search results: “TIP”

Showing 1–12 of 34 results

Publications Multiplex quantitative assays indicate a need for reevaluating reported small-molecule TrkB agonists

Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), have emerged as key regulators of brain plasticity and…

Publications Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays

By suppressing gene transcription through the recruitment of corepressor proteins, B-cell lymphoma 6 (BCL6) protein controls a transcriptional network required…

Scientific Posters Interrogating Allosteric Interactions Using Multiple Readouts for GPCRs

Compounds that bind to allosteric sites offer many benefits over those which interact orthosterically. These include enhanced specificity, ability to…

Publications Measurement of β-Arrestin Recruitment for GPCR Targets.

β-Arrestins are ubiquitously expressed in all cell types, and function in the desensitization of G- protein coupled receptors (GPCRs), the…

Publications Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine.

Extensive 3′ alternative splicing of the mu opioid receptor gene OPRM1 creates multiple C-terminal splice variants. However, their behavioral relevance…

Blogs & Articles Four Reasons Why You Should Measure and Quantify Signaling bias in Your Molecules

Most GPCRs are pleiotropically coupled to multiple signaling pathways in cells and the availability of functional assays to separately measure…

Scientific Posters [Wall Poster] The Druggable GPCRome

DiscoveRx offers an industry-leading portfolio of over 600 naturally coupled human and ortholog G-protein coupled receptor (GPCR) cell lines designed…

Application Notes InCELL Pulse Cellular Target Engagement Assays for Characterizing Novel Small Molecule Inhibitors of Oncogenic SHP2 Variants

SHP2 (Src-homology 2 domain-containing phosphatase 2) is a protein tyrosine phosphatase encoded by the human PTPN11 gene.SHP2 is a key…

Application Notes Automating a Cell-Based Target-Compound Assay for Methyltransferase and Bromodomain Proteins using the InCELL Hunter Platform

Histone modifications are essential in eukaryotic gene expression and regulation, and are driven by histone writer, eraser, and reader proteins.…

Case Studies Implementing Robust & Reproducible KILR® Ready-to-Use Bioassays from Screening to Lot Release: Applications for Measuring Direct Cytotoxic Cell Death

Therapeutic regulators require assay data on the impact of Fc effector-mediated function of antibodies during their development as therapeutics. The…

White Papers Accelerating Biosimilar & Biobetter Drug Development: Ready-to-Use, Cell-Based Assays for Potency and Lot Release Testing

With the drug industry’s expanding emphasis on biologics, the need for robust cell-based assays has grown at all stages of…

Webinars Duplexed Screening of GPCRs to Measure Calcium and β-Arrestin

The screening and functional characterization of novel ligands for G-Protein Coupled Receptors (GPCR) remains a key focus in drug discovery.…

Watch Now