FGFR1, active

N-terminal GST-tagged recombinant, human FGFR1 amino acids 456-765.

Catalog #: 14-582

$399.00$2,989.00


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Biological Information
Background Information:
Fibroblast growth factor (FGF) superfamily consists of 23 members, all of which contain a conserved 120 amino acid (aa) core region that contains six identical, interspersed amino acids. Based on the pI factor, two main groups of FGF are named: acidic FGF (aFGF) and basic FGF (bFGF). The superfamily members act extracellularly through four tyrosine kinase FGF receptors (FGFR1 through FGFR4), with multiple specificities noted for almost all FGFs. Biological binding of aFGF to its receptors will result in phosphorylation of the receptor and non-receptor proteins and generate its function. Overexpression and amplification of the fibroblast growth factor receptor-1 (FGFR-1), a prototypic receptor tyrosine kinase, have been found in tumor samples from human pancreas, breast, brain, prostate, thyroid gland, and salivary gland. GenBank NM_000604
Target Class:
Kinase
Family:
Receptor Typosine Kinase (RTK): Growth Factor Receptor
Accession Number:
Refer to CoA for Accession Number
Target Name:
FGFR1
Target Aliases:
FGFR1, CEK, bFGF-R, N-SAM, H5, FLT2, BFGFR, FGFR-1, c-fgr, FLG, H3, H2, KAL2, HBGFR, CD331, H4, FGFBR
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
Usage Disclaimer:
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Datasheets

14-582x Datasheet

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