Checkpoint Receptor Assays
MOA-reflective, functional cell-based assays to analyze signaling, dimerization, internalization, & clustering/crosslinking of checkpoint receptors.
Cytokine Receptor Product Solutions
Functional, MOA-reflective assays targeting human cytokine receptors for screening, characterization, QC lot release, & NAb studies.
Epigenetic Protein Product Solutions
Epigenetics target-based drug development products including bromodomain & methyltransferase target engagement stable cell lines & eXpress kits.
GPCR Product Solutions
GPCR cell-based functional assays for detecting ligand binding, second messengers, beta-arrestin recruitment, & GPCR internalization & trafficking.
Helicase Product Solutions
Validated, full-length recombinant helicases for robust screening, structural insights, & advanced mechanism of action research in drug discovery.
Ion Channel Solutions
Pharmacologically & functionally validated ion channel cell lines including voltage-gated, ligand-gated & others for drug discovery & safety applicati...Show More
Kinase Product Solutions
Kinase recombinant enzymes & functional & binding assays to assess kinase binding, receptor activation, dimerization, phosphorylation, & SH2-recruitme...Show More
Nuclear Protein Product Solutions
Functional cell-based assays to study nuclear protein translocation to the nucleus & ligand-induced activation of nuclear hormone receptors.
Signaling Pathway Product Solutions
Signal transduction pathway assays assess targets likc BCL2, TORC, p53, NF-kB, etc. for various pathways including apoptosis, DNA damage, ER stress et...Show More
Checkpoint Agonist Antibody Assays
Mechanistically relevant cell-based agonist antibody assays to evaluate and characterize agonism of antibodies targeting checkpoint receptors for immu...Show More
Kinase Activity Assay Kits
Validated, ready-to-use enzyme activity assays to assess small molecule enzyme & kinase inhibitors in drug discovery
Receptor Tyrosine Kinase Assays
Cell-based functional assays to assess dimerization, phosphorylation, internalization, & SH2-recruitment of RTK & cytokine receptors associated with C...Show More
ADP Accumulation Assays
ADP accumulation assays detect kinase activity & inhibition by measuring ADP accumulation in antibody-free and homogeneous assay formats.
GPCR Calcium Product Solutions
Measure intracellular calcium flux via GPCR signaling using stable cell lines, ready-to-assay kits, & HTS Calcium No WashPLUS detection kit.
GPCR cAMP Product Solutions
Detect cellular cAMP levels via GPCR signaling by biologics or small molecule therapeutics using robust, simple, homogeneous & HTS assays.
GPCR β-Arrestin Product Solutions
Universal G-protein independent cell-based assays to measure GPCR beta-arrestin recruitment and subsequent internalization upon ligand or therapeutic ...Show More