Cytokine Receptor Product Solutions

Comprehensive Portfolio of Cell-based, Functional Assays for Cytokines Receptors

Cytokines are a group of proteins that play a critical role in regulating the immune system and inflammation. The dysregulation of cytokines is associated with a wide range of diseases, including autoimmune disorders, cancer, and infectious diseases. Cytokine receptors are critical for cellular and extracellular communication in mediating immunological responses.

These receptors include type 1 and 2 cytokine-like interleukins, GM-CSF, interferons, chemokines, TNFα, TGF-β, and the Ig superfamily receptor types. All cytokine receptors are associated with one or more members of JAK kinases that couple the ligand binding to tyrosine phosphorylation of various STAT family transcription factors to the receptor complex.

Cytokines play a key role in the cytokine storm, a pro-inflammatory immune response, causing hyperinflammation and includes various cytokines such as interleukins (ILs), GM-CSF, chemokines, TNFα and more.

Therapeutics that target cytokines or their receptors can modulate the immune response and potentially treat these diseases. While the development of these drugs is complex and time-consuming and requires a deep understanding of the immune system and the role of cytokines in disease pathogenesis, assays are available to advance this discovery faster.

Eurofins DiscoverX^® offers a comprehensive portfolio of PathHunter^® cell-based, mechanism of action (MOA)-reflective, functional assays to enable the study and targeting of cytokine receptors, covering over 85% of human interleukins (IL-1 to IL-37) and their receptors.

These assays are designed to be highly specific and reproducible, include a simple protocol, and have a large signal-to-noise ratio and matrix tolerance. These cytokine receptor assays have enabled their broad application in functional screening, functional characterization, QC lot release assays, and neutralizing antibody studies.