Consider Eurofins DiscoverX’s custom development capabilities for custom cell lines, assays, & enzyme development.
G protein-coupled receptors (GPCRs) are 7-transmembrane receptors representing the largest family of validated therapeutic targets with over 800 known human GPCRs. Therapeutics targeting GPCRs represent over 40% of all currently marketed drug therapeutics acting on GPCRs either directly or indirectly. GPCRs have a broad array of ligands, including growth factors, ions, lipids, nucleotides, hormones, and neurotransmitters.
Their physiological and pathological involvements are vast, ranging from regulation of hunger to the development of fetal structures, and from roles in cardiovascular disorders to rare diseases. To help researchers fully characterize their specific GPCR of interest, and the small molecules or biologics effecting their activity, Eurofins DiscoverX® encourages exploring all possible signaling scenarios with a variety of available biologically-relevant cell-based functional and binding assays, cell lines, detection kits, and membrane preparations.
The target-specific products in the Eurofins DiscoverX portfolio are sensitive, scalable, and robust for detecting receptor-mediated second messenger signals (cAMP and calcium), β-arrestin recruitment, receptor internalization, and ligand binding. These assays also support the characterization of orphan GPCRs without a known ligand or approved drug as part of the comprehensive GPCR solutions portfolio offered.
Consider Eurofins DiscoverX’s custom development capabilities for custom cell lines, assays, & enzyme development.
Eurofins DiscoverX GPCR products for specific known, orphan, or ortholog (multiple species) GPCRs.