Consider Eurofins DiscoverX’s custom development capabilities for custom cell lines, assays, & enzyme development.
cAMP cell-based assays measure cAMP levels in cells as a direct indication of GPCR functional status (activation or inhibition). This direct measurement is obtained by quantifying cellular cAMP accumulation levels in a dose-dependent manner with cell-based assays that are homogeneous and scalable.
Eurofins DiscoverX® provides robust, easy-to-use, and high throughput screening (HTS) HitHunter® cAMP cell-based assays that accurately detect cellular cAMP levels in a variety of applications without the need for wash steps, optimization, or specialized equipment. These versatile assays provide a simple, validated detection system, optimized with over 125 cAMP Hunter™ cell lines, and include large signal-to-background, gain-of-signal responses. They can be used to monitor GPCR activation or inhibition with cAMP Hunter, ChemiSCREEN™, or non-Eurofins DiscoverX cell lines. Easily obtain reproducible results with high sensitivity, rank order ligands based on molecular potency, or determine pharmacological profiles of your ligands.
Used in the screening of millions of data points and referenced in hundreds of peer reviewed publications ranging from basic research to clinical applications, these assays provide accurate pharmacology of your ligand or small molecule and biologics while giving you the flexibility to work with multiple cell lines.
Consider Eurofins DiscoverX’s custom development capabilities for custom cell lines, assays, & enzyme development.