Consider Eurofins DiscoverX’s custom development capabilities for custom cell lines, assays, & enzyme development.
Regulation of immune responses is tightly controlled through a balance of co-stimulatory and inhibitory checkpoint receptors often exploited by many cancers. Therefore, therapeutics that block inhibitory receptors or activate immune-stimulatory checkpoint receptors, such as PD-1 receptor, have proven to be powerful agents to restore anti-tumor immune responses.
Eurofins DiscoverX® offers a large, diverse selection of assays for characterization, screening, and potency QC lot-release testing of immunotherapy therapeutics targeting both inhibitory and co-stimulatory checkpoint receptors. Utilize PathHunter® functional, mechanism of action (MOA)-reflective cell-based checkpoint receptor assays to analyze signaling, dimerization, internalization, and clustering/crosslinking of checkpoint receptors. These simple, rapid assays provide a highly sensitive response for most targets without primary cells or complex protocols in a few hours for most targets without primary cells or complex protocols.
Consider Eurofins DiscoverX’s custom development capabilities for custom cell lines, assays, & enzyme development.
PathHunter checkpoint assays are available as complete ready-to-use bioassay kits and stable cell lines formats for checkpoint receptor dimerization, signaling, clustering, and internalization assessment. For additional checkpoint receptor cell lines not shown below, please contact custom assay development (CAD) for more information.
Eurofins DiscoverX helps accelerate the entry of your therapeutic molecule to market for the latest and most researched targets with a list of early access cell lines and ready-to-use assay kits.
Target | Assay Measures | Cat. No. |
---|---|---|
PD-1/LAG3 | Receptor Dimerization | Inquire |
PD-1/CTLA4 | Receptor Dimerization | Inquire |
PD-1/TIGIT | Receptor Dimerization | Inquire |
PD-L1/TIM3 | Receptor Dimerization | Inquire |
PD-1/PD-L1 | Receptor Dimerization | Inquire |
PD-L1/CTLA4 | Receptor Dimerization | Inquire |
PD-1/CEACAM1 | Receptor Dimerization | Inquire |
TIM3/CEACAM1 | Receptor Dimerization | Inquire |
TIGIT/LAG3 | Receptor Dimerization | Inquire |
PD-1/CD28 | Receptor Dimerization | Inquire |
mPD-1/mLAG3 | Receptor Dimerization | Inquire |
mPD-1/mTIGIT | Receptor Dimerization | Inquire |
mPD-1/mCTLA4 | Receptor Dimerization | Inquire |