Consider Eurofins DiscoverX’s custom development capabilities for custom cell lines, assays, & enzyme development.
Epigenetics involves the study of heritable or acquired changes in gene expression caused by non-genetic mechanisms without alterations in gene structure or sequence. Basic epigenetic mechanisms such as histone modifications, DNA methylation, and chromatin remodeling are essential in the regulation of many physiological processes. Alterations to the mechanisms -- either by modifications to DNA and histone components of nucleosomes, or by expression of noncoding RNAs (ncRNAs) -- can have implications in a number of cancers, immunological, and neurodegenerative conditions.
Eurofins DiscoverX® offers epigenetics recombinant proteins and InCELL Hunter™ cell-based assays for studying the modulation of epigenetic mechanisms and identifying small molecule inhibitors and modifiers of DNA methyltransferases and bromodomains. Utilize InCELL Hunter cell-based compound-target engagement assays to confirm small molecule compound cell entry and epigenetic target binding, screen and rank inhibitors, validate hits identified in biochemical assays, and measure cellular EC50 values all in the native cellular environment.
Consider Eurofins DiscoverX’s custom development capabilities for custom cell lines, assays, & enzyme development.