| Biological Information | |
|---|---|
| Background Information: | TAO3 is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. In response to DNA damage, TAO3 is involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases.
GenBank NM_016281. The recombinant protein contains the amino acid substitution N47S with reference to NM-016281. This mutation is reported in GenBank BC002756 and BC7007185 |
| Target Class: | Kinase |
| Accession Number: | NM_016281.3 |
| Target Name: | TAO3 |
| Target Aliases: | TAOK3, JIK, hKFC-A, MAP3K18, DPK, KDS, DKFZp666H245, FLJ31808 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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TAO3, active
N-terminal 6His-tagged recombinant, human TAO3 amino acids 1-411; N47S.
Datasheets
14-745x Datasheet
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