| Biological Information | |
|---|---|
| Background Information: | Wortmannin is a natural product that potently inhibits PI3K with anti-inflammatory and immunosuppressant effects in vivo. It has been used extensively in the study of insulin-regulated events in a variety of cells. It was also used to study the activation of PI3K by other growth factors, such as platelet-derived growth factor. Wortmannin was reported to block insulin-stimulated expression of lipogenic genes, such as Srebp-1c and Acc. It also blocked insulin-stimulated glycogen synthase, S6K, Akt, and GSK-3 activities. Interestingly, it has been reported that Wortmannin also inhibited the activity of smooth muscle myosin light-chain kinase. (Modern Methods in Natural Products Chemistry, 9.17.3.3.4 Wortmannin, 2010) |
| Target Name: | Wortmannin |
| Usage | |
| Product Type: | Control Ligands & Inhibitors |
| Application: | Drug Discovery & Development |
| Storage Conditions: | Store at ≤-20°C. Please avoid multiple freeze/thaw cycles. |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
| Additional Information | |
| Brand: | DiscoverX |
Wortmannin
Wortmannin is a naturally occurring steroid metabolite that potently inhibits phosphatidylinositol 3-kinases. Wortmannin also inhibits PLK1, PLK3, MTOR, DNAPK, PI4Ks, MLCK, and MAPK at higher concentrations.
Datasheets
92-1095 Datasheet
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