Upon DNA damage, ataxia telangiectasia mutated (ATM) kinase triggers multiple events to promote cell survival and facilitate repair. If damage is excessive, ATM stimulates cytokine secretion to alert neighboring cells and apoptosis to eliminate the afflicted cell. ATM augments...
10/3/2012 5:51:28 PM
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle protei...
2/12/2015 9:46:31 PM
Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cell...
2/12/2015 9:46:15 PM
Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates ...
2/12/2015 9:46:29 PM
Kinase Solutions Cellular Kinase Assays and Purified Kinases for Drug Discovery Screening and Lead Optimization Eurofins DiscoverX offers a variety of kinase products with complete human kinome coverage so you can always find a solution for your kinase target. ...
7/28/2017 6:13:26 PM
Contact a Specialist Products Kinases – View over 440 active, inactive, and unactivated kinases available as human, mouse, rat, and other species; expressed from bacterial, insect, or mammalian cells Phosphatases – Utilize the same phosphatase, expressed in E. coli...
9/24/2019 1:24:47 PM