/products/proteins/14-530
/products/proteins/14-530m
/products/proteins/14-557
/products/proteins/14-557m
The mitogen-activated protein kinase (MAPK) signal transduction pathway plays a central role in regulating tumor cell growth, survival, differentiation, and angiogenesis. The key components of the Ras/Raf/MEK/ERK signal module are frequently altered in human cancers. Targeting...
/tools-resources/publications-references/publications/characterization-of-a-novel-mitogen-activated-prot
10/3/2012 5:51:33 PM
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated wi...
/target-data-sheets/kinase/braf(v600e)
2/12/2015 9:46:19 PM
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated wi...
/target-data-sheets/kinase/braf
2/12/2015 9:46:19 PM
Kinases are known to regulate fundamental processes in cancer including tumor proliferation, metastasis, neovascularization, and chemoresistance. Accordingly, kinase inhibitors have been a major focus of drug development, and several kinase inhibitors are now approved for vari...
/tools-resources/publications-references/publications/disruption-of-angiogenesis-and-tumor-growth-with-a
10/3/2012 5:51:32 PM
This white paper describes a profiling strategy that includes both in vitro and in vivo approaches to characterize sorafenib, an ATP-competitive multi-kinase inhibitor with clinical applications in multiple cancer types. Data for vemurafenib, an anti-neoplastic B-Raf kina...
/tools-resources/document-resource-library/documents/white-paper-profiling-oncology-drug-candidates-through-complementary-in-vitro-assays-and-in-vivo-mo
8/9/2019 10:44:36 AM