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B-Raf (δ1-415), active

/products/proteins/14-530
B-Raf (δ1-415), active

/products/proteins/14-530m
B-Raf (V599E), active

/products/proteins/14-557
B-Raf (V599E), active

/products/proteins/14-557m
Characterization of a novel mitogen-activated protein kinase kinase 1/2 inhibitor with a unique mechanism of action for cancer therapy.
The mitogen-activated protein kinase (MAPK) signal transduction pathway plays a central role in regulating tumor cell growth, survival, differentiation, and angiogenesis. The key components of the Ras/Raf/MEK/ERK signal module are frequently altered in human cancers. Targeting...
/tools-resources/publications-references/publications/characterization-of-a-novel-mitogen-activated-prot 10/3/2012 5:51:33 PM
v-raf murine sarcoma viral oncogene homolog B1 (BRAF(V600E))
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated wi...
/target-data-sheets/kinase/braf(v600e) 2/12/2015 9:46:19 PM
v-raf murine sarcoma viral oncogene homolog B1 (BRAF)
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated wi...
/target-data-sheets/kinase/braf 2/12/2015 9:46:19 PM
Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF.
Kinases are known to regulate fundamental processes in cancer including tumor proliferation, metastasis, neovascularization, and chemoresistance. Accordingly, kinase inhibitors have been a major focus of drug development, and several kinase inhibitors are now approved for vari...
/tools-resources/publications-references/publications/disruption-of-angiogenesis-and-tumor-growth-with-a 10/3/2012 5:51:32 PM
White Paper: Profiling Oncology Drug Candidates Through Complementary in vitro Assays and in vivo Models to Better Understand Their Potential Clinical Applications
This white paper describes a profiling strategy that includes both in vitro and in vivo approaches to characterize sorafenib, an ATP-competitive multi-kinase inhibitor with clinical applications in multiple cancer types. Data for vemurafenib, an anti-neoplastic B-Raf kina...
/tools-resources/document-resource-library/documents/white-paper-profiling-oncology-drug-candidates-through-complementary-in-vitro-assays-and-in-vivo-mo 8/9/2019 10:44:36 AM
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