This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert...
/target-data-sheets/kinase/flt3
2/12/2015 9:44:00 PM
/products/proteins/14-500
/products/proteins/14-500m
For a subpopulation of acute myeloid leukemia (AML) patients, the constitutively activated tyrosine kinase, mutant FLT3, has emerged as a promising target for therapy. The development of drug resistance, however, is a growing concern for mutant FLT3 inhibitors, such as PKC4...
/tools-resources/publications-references/publications/discovery-and-characterization-of-novel-mutant-flt
10/3/2012 5:51:32 PM
Activating mutations in the receptor tyrosine kinase FLT3 are present in up to approximately 30% of acute myeloid leukemia (AML) patients, implicating FLT3 as a driver of the disease and therefore as a target for therapy. We report the characterization of AC220, a second-gener...
/tools-resources/publications-references/publications/ac220-is-a-uniquely-potent-and-selective-inhibitor
10/3/2012 5:51:26 PM
/products/proteins/14-610
/products/proteins/14-610m
/products/assay/flt3-activity-assay-93-0901e3cp16m
/products/assay/flt3-activityassay-93-0901e3cp16l
/products/cell-line/u2os-flt3-activity-assay-93-0901c3
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