/products/proteins/14-645
/products/proteins/14-645m
interleukin-1 receptor-associated kinase 2 [ Homo sapiens (human) ]
/target-data-sheets/kinase/irak2
1/6/2016 9:16:54 AM
After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encod...
/target-data-sheets/kinase/insr
2/12/2015 9:47:13 PM
/products/proteins/14-599
/products/proteins/14-599m
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription f...
/target-data-sheets/kinase/irak1
2/12/2015 9:47:14 PM
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococc...
/target-data-sheets/kinase/irak4
2/12/2015 9:47:15 PM
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a ...
/target-data-sheets/kinase/irak3
2/12/2015 9:47:14 PM
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endo...
/target-data-sheets/kinase/ern1
2/12/2015 9:46:57 PM
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