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JAK2, active

/products/proteins/14-640
JAK2, active

/products/proteins/14-640m
Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation.
Janus kinase 2 (JAK2) signal transduction is a critical mediator of the immune response. JAK2 is implicated in the onset of graft-versus-host disease (GVHD), which is a significant cause of transplant-related mortality after allogeneic hematopoietic cell transplantation (allo...
/tools-resources/publications-references/publications/jak2-gvhd-xenograft-rejection-t-cell-differentiati 8/21/2020 10:58:04 PM
Erythropoietin receptor (EpoR)

/target-data-sheets/cytokine/epor-jak2 2/12/2015 9:43:53 PM
Janus kinase 1 (JAK1(JH1domain-catalytic))
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein k...
/target-data-sheets/kinase/jak1(jh1domain-catalytic) 2/12/2015 9:47:15 PM
Janus kinase 1 (JAK1(JH2domain-pseudokinase))
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein k...
/target-data-sheets/kinase/jak1(jh2domain-pseudokinase) 2/12/2015 9:47:16 PM
Janus kinase 2 (JAK2(JH1domain-catalytic))
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an a...
/target-data-sheets/kinase/jak2(jh1domain-catalytic) 2/12/2015 9:47:16 PM
Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures.
Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling is critical to multiple cellular processes, including survival, differentiation, and proliferation. JAK-STAT signaling dysregulation has been noted in inflammatory disorders, and aberrant JAK...
/tools-resources/publications-references/publications/compare-phenotypic-profile-jak2-inhib-mechanisms 10/11/2019 1:10:58 PM
PathHunter® eXpress GHR-JAK2 Functional Assay

/products/assay/ghr-jak2-functional-assay-93-0829e3cp14m
PathHunter® eXpress GHR-JAK2 Functional Assay

/products/assay/ghr-jak2-functional-assay-93-0829e3cp14l
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