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leucine-rich repeat kinase 2 (LRRK2)
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is presen...
/target-data-sheets/kinase/lrrk2 2/12/2015 9:47:23 PM
LRRK2, active

/products/proteins/14-919
LRRK2, active

/products/proteins/14-919m
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.
Mutations in leucine-rich repeat kinase 2 (LRRK2) are strongly associated with late-onset autosomal dominant Parkinson's disease. We employed a new, parallel, compound-centric approach to identify a potent and selective LRRK2 inhibitor, LRRK2-IN-1, and demonstrated that inh...
/tools-resources/publications-references/publications/characterization-of-a-selective-inhibitor-of-the-p 10/3/2012 5:51:29 PM
leucine-rich repeat kinase 2 (LRRK2(G2019S))
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is presen...
/target-data-sheets/kinase/lrrk2(g2019s) 2/12/2015 9:47:23 PM
Gene Symbol
KINOME scan Gene Symbol td:first-child { background-color:#FFFFCC; } KINOMEscan Gene Symbol Entrez Gene Symbol Accession Number AAK1 AAK1 NP_055726.3 ABL1(E255K)-phosphorylated ABL1 NP_005148.2 ABL1(F317I)...
/services/drug-discovery-development-services/kinase-profiling/kinomescan/gene-symbol 3/4/2016 8:11:57 PM
Mutant Kinase Reference Guide
Mutant Kinase Reference Guide Understanding Compound Selectivity in Mutant Kinases Protein kinases play an integral role as mediators of multiple signal transduction pathways and are responsible for the modulation of essential cellular functions including cell proliferatio...
/tools-resources/document-resource-library/mutant-kinase-reference-guide 10/9/2012 10:09:17 PM
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