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MKK4/SKK1, active

/products/proteins/14-377
MKK4/SKK1, active

/products/proteins/14-377m
MKK4/SKK1, unactive

/products/proteins/14-378
MKK4/SKK1, unactive

/products/proteins/14-378m
mitogen-activated protein kinase kinase kinase 9 (MLK1)
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal t...
/target-data-sheets/kinase/mlk1 2/12/2015 9:47:34 PM
mitogen-activated protein kinase kinase kinase 5 (ASK1)
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/...
/target-data-sheets/kinase/ask1 2/12/2015 9:46:15 PM
mitogen-activated protein kinase kinase kinase 10 (MLK2)
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK s...
/target-data-sheets/kinase/mlk2 2/12/2015 9:47:34 PM
mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MK...
/target-data-sheets/kinase/map4k4 2/12/2015 9:47:27 PM
mitogen-activated protein kinase kinase 4 (MEK4)
This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and...
/target-data-sheets/kinase/mek4 2/12/2015 9:47:30 PM
mitogen-activated protein kinase kinase kinase 7 (TAK1)
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apop...
/target-data-sheets/kinase/tak1 2/12/2015 9:48:26 PM
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