We devised a high-throughput chemoproteomics method that enabled multiplexed screening of 16,000 compounds against native protein and lipid kinases in cell extracts. Optimization of one chemical series resulted in CZC24832, which is to our knowledge the first selective inhibi...
/tools-resources/publications-references/publications/selective-inhibitor-pi3kγ-t(h)17-differentiation
4/8/2019 3:33:55 PM
PI3Kδ and PI3Kγ regulate immune cell signaling, while the related PI3Kα and PI3Kβ regulate cell survival and metabolism. Selective inhibitors of PI3Kδ/γ represent a potential class of anti-inflammatory agents lacking the antiproliferative effects associated with PI3Kα/β inhib...
/tools-resources/publications-references/publications/dual-pi3ks-inhibitors-anti-inflammatory-prototype
4/8/2019 3:20:40 PM
BioMAP ® Frequently Asked Questions (FAQ) Request a Quote BioMAP Platform What is BioMAP profiling? BioMAP profiling is in vitro and high throughput characterization of the clinically relevant biological effects of test agents (small molecules, biologics, etc....
/services/drug-discovery-development-services/primary-cell-phenotypic-profiling/faq
2/9/2016 2:42:52 AM
BioMAP ® Frequently Asked Questions (FAQ) Request a Quote BioMAP Platform What is BioMAP profiling? BioMAP profiling is in vitro and high throughput characterization of the clinically relevant biological effects of test agents (small molecules, biologics, etc....
/tools-resources/drug-discovery-development-services/primary-cell-phenotypic-profiling/faq
4/29/2020 10:04:15 AM