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Syk, active

/products/proteins/14-314
Syk, active

/products/proteins/14-314m
Spleen tyrosine kinase (SYK)
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including pr...
/target-data-sheets/kinase/syk 2/12/2015 9:45:51 PM
PathHunter® eXpress SYK Activity Assay

/products/assay/syk-activity-assay-93-0865e3cp16m
PathHunter® eXpress SYK Activity Assay

/products/assay/syk-activity-assay-93-0865e3cp16l
PathHunter® U2OS SYK Activity Assay

/products/cell-line/u2os-syk-activity-assay-93-0865c3
Application of a phenotypic drug discovery strategy to identify biological and chemical starting points for inhibition of TSLP production in lung epithelial cells.
Thymic stromal lymphopoietin (TSLP) is a cytokine released by human lung epithelium in response to external insult. Considered as a master switch in T helper 2 lymphocyte (Th2) mediated responses, TSLP is believed to play a key role in allergic diseases including asthma. The ...
/tools-resources/publications-references/publications/phenotypic-strategy-inhibit-tslp-lung-epitheli-(1) 1/24/2020 10:29:02 AM
Complex Primary Human Cell Systems for Drug Discovery. In: Human-based Systems for Translational Research.
Phenotypic or biofunctional assays play an important role in drug discovery by helping to bridge the gap between high-throughput, target-based screening assays used for compound identification and more physiologically relevant  in vivo  disease models used for preclinical dev...
/tools-resources/publications-references/publications/complex-primary-human-cell-systems-drug-discovery 4/8/2019 4:20:34 PM
Gene Symbol
KINOME scan Gene Symbol td:first-child { background-color:#FFFFCC; } KINOMEscan Gene Symbol Entrez Gene Symbol Accession Number AAK1 AAK1 NP_055726.3 ABL1(E255K)-phosphorylated ABL1 NP_005148.2 ABL1(F317I)...
/services/drug-discovery-development-services/kinase-profiling/kinomescan/gene-symbol 3/4/2016 8:11:57 PM
Reassessment of the pharmacology of sphingosine-1-phosphate S1P(3) receptor ligands using the DiscoveRx PathHunter and Ca(2+) release functional assays.
BACKGROUND AND PURPOSE: DiscoverRx's PathHunter assay measures GPCR agonist potency, via the recruitment of β-arrestin, independent of the subtype of G(α) protein activated. This assay is frequently used in drug discovery although little is known about the agonist pharma...
/tools-resources/publications-references/publications/reassessment-of-the-pharmacology-of-sphingosine-1 2/27/2013 10:11:10 PM
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