/target-data-sheets/kinase/trka-p75
2/12/2015 9:45:58 PM
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and...
/target-data-sheets/kinase/trka
2/12/2015 9:45:58 PM
/products/assay/trka-functional-assay-93-0462e3cp16m
/products/assay/trka-functional-assay-93-0462e3cp16l
/products/cell-line/u2os-trka-functional-assay-93-0462c3
/products/proteins/14-571
/products/proteins/14-571m
A series of substituted indoles were examined as selective inhibitors of tropomyosin-related kinase receptor A (TrkA), a therapeutic target for the treatment of pain. An SAR optimization campaign based on ALIS screening lead compound 1 is reported.
/tools-resources/publications-references/publications/design-synthesis-and-sar-of-substituted-indoles
11/17/2017 7:34:49 PM
The PathHunter™ technology from DiscoveRx is an adaptation of Enzyme Fragment Complementation (EFC) that provides a novel, generic cell-based assay format for detecting protein-protein interactions. This approach has enabled development of a number of new screening and profili...
/tools-resources/document-resource-library/documents/new-cell-based-kinase-assays-for-trka-and-other-re
10/9/2012 10:09:05 PM
The TrkA-PathHunter cell-based assay was used in high-throughput screening (HTS) to identify compounds that inhibit nerve growth factor (NGF)/TrkA signaling. The assay was conducted in a 384-well format, and typical Z' values during HTS ranged from 0.3 to 0.8. The...
/tools-resources/publications-references/publications/the-use-of-trka-pathhunter-assay
3/12/2013 4:42:29 PM
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