The mitogen-activated protein kinase (MAPK) signal transduction pathway plays a central role in regulating tumor cell growth, survival, differentiation, and angiogenesis. The key components of the Ras/Raf/MEK/ERK signal module are frequently altered in human cancers. Targeting...
/tools-resources/publications-references/publications/characterization-of-a-novel-mitogen-activated-prot
10/3/2012 5:51:33 PM
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phospho...
/target-data-sheets/kinase/raf1
2/12/2015 9:48:09 PM