/products/proteins/14-952
/products/proteins/14-952m
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a ...
/target-data-sheets/pathways/p53
2/12/2015 9:45:23 PM
/products/cell-line/u2os-p53-nuclear-translocation-cell-line-93-0757c3
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues...
/target-data-sheets/kinase/gak
2/12/2015 9:47:06 PM
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulati...
/target-data-sheets/kinase/lats2
2/12/2015 9:47:21 PM
This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppress...
/target-data-sheets/kinase/adck3
2/12/2015 9:46:10 PM
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and develo...
/target-data-sheets/kinase/jnk2
2/12/2015 9:47:17 PM
/products/reagent/doxorubicin-hydrochloride-92-1101
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/...
/target-data-sheets/kinase/plk1
2/12/2015 9:48:03 PM
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