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BROMOscan® - Bromodomain Assay Panel

BROMOscan is a novel industry leading platform for identifying small molecule bromodomain inhibitors. Bromodomains are epigenetic “reader” proteins that have emerged as an important new druggable target class in small molecule inhibitor drug discovery with several bromodomain-containing proteins being associated with disease.

Expanded BROMOscan Panel - Now 40 assays available! Learn More»

Based on the proven KINOMEscan® technology, BROMOscan is a robust and highly sensitive quantitative binding platform that can be applied to high throughput screening and selectivity profiling to facilitate the identification of potent and selective small molecule bromodomain inhibitors.
 

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Panel Highlights and Benefits

  • Growing menu of 40 screening-ready, quantitative
    binding bromodomain assays
  • Rigorous assay validation with state-of-the-art benchmark epigenetic inhibitors
  • Flexible service options - library screening, selectivity profiling and quantitative Kd follow-up
  • Rapid turnaround - data delivered in 2 weeks
  How it Works
 

Overview of BROMOscan℠ Panels & Services

Services Assays Pre-configured Panel Customizable? Standard Turnaround
bromoMAX 32 Yes No 20 days
bromoELECT 1-32 No Yes 20 days
bromoKdELECT 1-40 No Yes 10 days
bromoKdMAX 40 Yes No 10 days

Bromodomain Assay List

Below is a complete list of available BROMOscan assays.  The list can be sorted by "BROMOscan Gene Symbol" (BGS), "Bromodomain Protein Name", or "Entrez Gene Symbol".

 

BGS ▲Bromodomain Protein NameEntrez Gene Symbol
ATAD2AATPase family AAA domain-containing protein 2ATAD2
ATAD2BATPase family, AAA domain containing 2BATAD2B
BAZ2Abromodomain adjacent to zinc finger domain, 2ABAZ2A
BAZ2Bbromodomain adjacent to zinc finger domain, 2BBAZ2B
BRD1bromodomain-containing protein 1BRD1
BRD2(1)bromodomain-containing protein 2 isoform 1, bromodomain 1BRD2
BRD2(2)bromodomain-containing protein 2 isoform 1, bromodomain 2BRD2
BRD3(1)bromodomain-containing protein 3, bromodomain 1BRD3
BRD3(2)bromodomain-containing protein 3, bromodomain 2BRD3
BRD4(1)bromodomain-containing protein 4 isoform long, bromodomain 1BRD4
BRD4(2)bromodomain-containing protein 4 isoform long, bromodomain 2BRD4
BRD7bromodomain containing 7BRD7
BRD9bromodomain-containing protein 9 isoform 1BRD9
BRDT(1)bromodomain testis-specific protein isoform b, bromodomain 1BRDT
BRDT(2)bromodomain testis-specific protein isoform b, bromodomain 2BRDT
BRPF1bromodomain and PHD finger containing, 1BRPF1
BRPF3bromodomain and PHD finger containing, 3BRPF3
CECR2cat eye syndrome chromosome region, candidate 2CECR2
CREBBPCREB binding proteinCREBBP
EP300E1A binding protein p300EP300
FALZnucleosome-remodeling factor subunit BPTF isoform 1BPTF
GCN5L2K(lysine) acetyltransferase 2AKAT2A
PBRM1(2)polybromo 1, bromodomain 2PBRM1
PBRM1(5)polybromo 1, bromodomain 5PBRM1
PCAFK(lysine) acetyltransferase 2BKAT2B
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2SMARCA2
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4SMARCA4
TAF1(2)TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa, bromodomain 2TAF1
TAF1L(2)TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like, bromodomain 2TAF1L
TRIM24(PHD,Bromo.)tripartite motif containing 24TRIM24
TRIM33(PHD,Bromo.)tripartite motif containing 33TRIM33
WDR9(2)bromodomain and WD repeat domain containing 1, bromodomain 2BRWD1