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GPCR Assay Formats and Services Offered

Below is a list of all the GPCR assays and readouts that DiscoverX offers.

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Family ▲TargetCommon NameArrestincAMPCalciumInternalization
5-HydroxytryptamineHTR1A5-hydroxytryptamine receptor 1A (5HT1A)XX  
5-HydroxytryptamineHTR1B5-hydroxytryptamine receptor 1B (5HT1B)XX  
5-HydroxytryptamineHTR1E5-hydroxytryptamine receptor 1E (5HT1E)X   
5-HydroxytryptamineHTR1F5-hydroxytryptamine receptor 1F (5HT1F)XX  
5-HydroxytryptamineHTR2A5-hydroxytryptamine receptor 2A (5HT2A)X X 
5-HydroxytryptamineHTR2B5-hydroxytryptamine receptor 2B (5HT2B)  X 
5-HydroxytryptamineHTR2C5-hydroxytryptamine receptor 2C (5HT2C)X XX
5-HydroxytryptamineHTR2C(VGV)5-hydroxytryptamine receptor 2C - VGV isoform (5HT2C)X   
5-HydroxytryptamineHTR2C(VNV)5-hydroxytryptamine receptor 2C - VNV isoform (5HT2C)X   
5-HydroxytryptamineHTR2C(VSV)5-hydroxytryptamine receptor 2C - VSV isoform (5HT2C)X   
5-HydroxytryptamineHTR5A5-hydroxytryptamine receptor 5A (5HT5A)XX  
5-HydroxytryptamineHTR65-hydroxytryptamine receptor 6 (5HT6)X   
5-HydroxytryptamineHTR7D5-hydroxytryptamine receptor 7D (5HT7D) X  
5-HydroxytryptaminemHTR2A5-Hydroxytryptamine receptor 2A (m5HT2A)X   
5-HydroxytryptaminemHTR2C5-Hydroxytryptamine receptor 2C (m5HT2C)X   
5-HydroxytryptaminerHTR2C5-hydroxytryptamine receptor 2C (HTR2C)X   
AcetylcholinerCHRM4Cholinergic receptor, muscarinic 4 (rM4)X   
AcetylcholineCHRM1Cholinergic receptor, muscarinic 1 (M1)X XX
AcetylcholineCHRM2Cholinergic receptor, muscarinic 2 (M2)XX X
AcetylcholineCHRM3Cholinergic receptor, muscarinic 3 (M3)X XX
AcetylcholineCHRM4Cholinergic receptor, muscarinic 4 (M4)XX X
AcetylcholineCHRM5Cholinergic receptor, muscarinic 5 (M5)X XX
AdenosineADORA1Adenosine receptor A1 (A1)XX  
AdenosineADORA2AAdenosine receptor A2A (A2A)  X 
AdenosineADORA2BAdenosine receptor A2B (A2B) X  
AdenosineADORA3Adenosine receptor A3 (A3)XX  
AdenosinemADORA2BAdenosine receptor A2B (mA2B)X   
AdenosinemADORA3adenosine receptor A3 (mA3)X   
AdrenoceptorsADRA1AAdrenergic receptor alpha 1A (α1A-adrenoceptor)  X 
AdrenoceptorsADRA1BAdrenergic receptor alpha 1B (α1B-adrenoceptor)X X 
AdrenoceptorsADRA1D(82-572)Adrenergic receptor alpha 1D (α1D-adrenoceptor)X   
AdrenoceptorsADRA2AAdrenergic receptor alpha 2A (α2A-adrenoceptor)XX  
AdrenoceptorsADRA2BAdrenergic receptor alpha 2B (α2B-adrenoceptor)X   
AdrenoceptorsADRA2CAdrenergic receptor alpha 2C (α2C-adrenoceptor)XX X
AdrenoceptorsADRB1Adrenergic receptor beta 1 (β1-adrenoreceptor)XX  
AdrenoceptorsADRB2Adrenergic receptor beta 2 (β2-adrenoreceptor)XX X
AdrenoceptorsADRB3Adrenergic receptor beta 3 (β3-adrenoreceptor) X  
AngiotensinAGTR1Angiotensin II receptor, type 1 (AT1)X X 
ApelinAGTRL1Apelin receptor (APJ)XX X
ApelinmAGTRL1Apelin receptor (mAPJ)X   
Bile acidGPBAR1G protein-coupled bile acid receptor 1 (GPBA)XX  
BombesinBRS3Bombesin receptor, subtype 3 (BB3)X X 
BombesinGRPRGastrin releasing peptide receptor (BB2)X XX
BombesinNMBRNeuromedin B Receptor (BB1)X XX
BradykininBDKRB1Bradykinin receptor B1 (B1)X X 
BradykininBDKRB2Bradykinin receptor B2 (B2)X XX
CalcitoninCALCRCalcitonin receptor (CT)XX  
CalcitoninCALCRL-RAMP1Calcitonin receptor-like (Calcitonin receptor-like receptor)XX  
CalcitoninCALCRL-RAMP2Calcitonin receptor-like (Calcitonin receptor-like receptor)X   
CalcitoninCALCRL-RAMP3Calcitonin receptor-like (Calcitonin receptor-like receptor)XX  
CalcitoninCALCR-RAMP2Calcitonin receptor (CT)XX  
CalcitoninCALCR-RAMP3Calcitonin receptor (CT)XX  
Calcium sensingCASRCalcium-sensing receptor (CaS)  X 
CannabinoidCNR1Cannabinoid receptor 1 (CB1)XX  
CannabinoidCNR2Cannabinoid receptor 2 (CB2)XX  
CannabinoidmCNR1Cannabinoid receptor 1 (mCB1)X   
CannabinoidmCNR2Cannabinoid receptor 2 (mCB2)X   
CannabinoidrCNR2Cannabinoid receptor 2 (CB2)X   
ChemerinCMKLR1Chemokine-like receptor 1 (CMKLR1)XX X
ChemokineCCR1Chemokine (C-C motif) receptor 1 (CCR1)XX X
ChemokineCCR10Chemokine (C-C motif) receptor 10 (CCR10)XX X
ChemokineCCR2Chemokine (C-C motif) receptor 2 (CCR2)X  X
ChemokineCCR3Chemokine (C-C motif) receptor 3 (CCR3)X   
ChemokineCCR4Chemokine (C-C motif) receptor 4 (CCR4)X  X
ChemokineCCR5Chemokine (C-C motif) receptor 5 (CCR5)XX X
ChemokineCCR6Chemokine (C-C motif) receptor 6 (CCR6)XX X
ChemokineCCR7Chemokine (C-C motif) receptor 7 (CCR7)XX X
ChemokineCCR8Chemokine (C-C motif) receptor 8 (CCR8)X   
ChemokineCCR9Chemokine (C-C motif) receptor 9 (CCR9)X   
ChemokineCCRL1chemokine (C-C motif) receptor-like 1 (CCRL1)X   
ChemokineCCRL2Chemokine (C-C motif) receptor-like 2 (CCRL2)X   
ChemokineCX3CR1Chemokine C-X3-C receptor 1 (CX3CR1)X   
ChemokineCXCR1Chemokine (C-X-C motif) receptor 1 (CXCR1)XX X
ChemokineCXCR2Chemokine (C-X-C motif) receptor 2 (CXCR2)XX X
ChemokineCXCR3Chemokine (C-X-C motif) receptor 3 (CXCR3)XX X
ChemokineCXCR4Chemokine (C-X-C motif) receptor 4 (CXCR4)XX X
ChemokineCXCR5Burkitt lymphoma receptor (CXCR5)XX  
ChemokineCXCR6Chemokine (C-X-C motif) receptor 6 (CXCR6)X   
ChemokineCXCR7Chemokine (C-X-C motif) receptor 7 (CXCR7)X  X
Chemokinecyno CXCR1Chemokine (C-X-C motif) receptor 1 (CXCR1)X   
Chemokinecyno CXCR2Chemokine (C-X-C motif) receptor 2 (CXCR2)X   
ChemokineDARCDuffy blood group, chemokine receptor (FY)X   
ChemokinemCMKLR1Chemokine-Like Receptor 1 (mCMKLR1)X   
ChemokinemCCR1Chemokine (C-C motif) receptor 1 (mCC1)X   
ChemokinemCCR2Chemokine (C-C motif) receptor 2 (mCCR2)X   
ChemokinemCCR3Chemokine (C-C motif) receptor 3 (mCCR3)X   
ChemokinemCCR4Chemokine (C-C motif) receptor 4 (mCCR4)X   
ChemokinemCCR5Chemokine (C-C motif) receptor 5 (mCCR5)X   
ChemokinemCCR6Chemokine (C-C motif) receptor 6 (mCCR6)X   
ChemokinemCCR7Chemokine (C-C motif) receptor 7 (mCCR7)X   
ChemokinemCCR8Chemokine (C-C motif) receptor 8 (mCCR8)X   
Chemokine mCCR9Chemokine (C-C motif) receptor 9 (mCCR9)X   
ChemokinemCX3CR1Chemokine (C-X3-C motif) receptor 1 (mCX3CR1)X   
ChemokinemCXCR2Chemokine (C-X-C motif) receptor 2 (mCXCR2)X   
ChemokinemCXCR3Chemokine (C-X-C motif) receptor 3 (mCXCR3)X   
ChemokinemCXCR4Chemokine (C-X-C motif) receptor 4 (mCXCR4)X   
ChemokinemCXCR5Burkitt lymphoma receptor (mCXCR5)X   
ChemokinemCXCR6Chemokine (C-X-C motif) receptor 6 (mCXCR6)X   
ChemokinemCXCR7Chemokine (C-X-C motif) receptor 7 (mCXCR7)X   
CholecystokininCCKARCholecystokinin A receptor (CCK1)X XX
CholecystokininCCKBRCholecystokinin B receptor (CCK2)X XX
Class A Orphancyno MRGPRX2MAS-related GPR, member X2 (MRGX2)X   
Class A OrphanEBI2G protein-coupled receptor 183 (GPR183)XX X
Class A OrphanGPR1G-protein coupled receptor 1 (GPR1)X  X
Class A OrphanGPR101G-protein coupled receptor 101 (GPR101)X   
Class A OrphanGHSR1bGrowth hormone secretagogue receptor 1b (GHSR1b)X   
Class A OrphanGPR119G-protein coupled receptor 119 (GPR119)X   
Class A OrphanGPR12G-protein coupled receptor 12 (GPR12)X   
Class A OrphanGPR139G-protein coupled receptor 139 (GPR139)X   
Class A OrphanGPR141G-protein coupled receptor 141 (GPR141)X   
Class A OrphanGPR142G-protein coupled receptor 142 (GPR142)X   
Class A OrphanGPR146G-protein coupled receptor 146 (GPR146)X   
Class A OrphanGPR148G-protein coupled receptor 148 (GPR148)X   
Class A OrphanGPR149G-protein coupled receptor 149 (GPR149)X   
Class A OrphanGPR15G-protein coupled receptor 15 (GPR15)X   
Class A OrphanGPR150G-protein coupled receptor 150 (GPR150)X   
Class A OrphanGPR151G-protein coupled receptor 151 (GPR151)X   
Class A OrphanGPR152G-protein coupled receptor 152 (GPR152)X   
Class A OrphanGPR161G-protein coupled receptor 161 (GPR161)X   
Class A OrphanGPR162G-protein coupled receptor 162 (GPR162)X   
Class A OrphanGPR17G-protein coupled receptor 17 (GPR17)X X 
Class A OrphanGPR171G-protein coupled receptor 171 (GPR171)X   
Class A OrphanGPR173G-protein coupled receptor 173 (GPR173)X   
Class A OrphanGPR176G-protein coupled receptor 176 (GPR176)X   
Class A OrphanGPR18G-protein coupled receptor 18 (GPR18)X   
Class A OrphanGPR182G-protein coupled receptor 182 (GPR182)X   
Class A OrphanGPR20G-protein coupled receptor 20 (GPR20)X   
Class A OrphanGPR22G-protein coupled receptor 22 (GPR22)X   
Class A OrphanGPR23Lysophosphatidic acid receptor 4 (LPA4)X   
Class A OrphanGPR25G-protein coupled receptor 25 (GPR25)X   
Class A OrphanGPR26G-protein coupled receptor 26 (GPR26)X   
Class A OrphanGPR27G-protein coupled receptor 27 (GPR27)X   
Class A OrphanGPR3G-protein coupled receptor 3 (GPR3)X   
Class A OrphanmEBI2G-protein coupled receptor 183 (GPR183)X   
Class A OrphanmGPR1G-Protein Coupled Receptor 1 (mGPR1)X   
Class A OrphanmGPR84G-protein coupled receptor 84, Mouse (GPR84)X   
Class A OrphanOPN5Opsin 5 (OPN5)X   
Class A OrphanMRGPRDMAS-related GPR, member D (MRGPRD)X   
Class A OrphanMRGPREMAS-related GPR, member E (MRGPRE)X   
Class A OrphanMRGPRFMAS-related GPR, member F (MRGPRF)X   
Class A OrphanMRGPRX1MAS-related GPR, member X1 (MRGPRX1)X X 
Class A OrphanMRGPRX2MAS-related GPR, member X2 (MRGX2)X X 
Class A OrphanMRGPRX4MAS-related GPR, member X4 (MRGPRX4)X   
Class A OrphanLGR4Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4)X   
Class A OrphanLGR5Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5)X   
Class A OrphanLGR6Leucine-rich repeat-containing G protein-coupled receptor 6 (LGR6)X   
Class A OrphanGPR132G-protein coupled receptor 132 (GPR132)X   
Class A OrphanGPR135G-protein coupled receptor 135 (GPR135)X   
Class A OrphanGPR83G-protein coupled receptor 83 (GPR83)X   
Class A OrphanGPR84G-protein coupled receptor 84 (GPR84)XX  
Class A OrphanGPR85G-protein coupled receptor 85 (GPR85)X   
Class A OrphanGPR88G-protein coupled receptor 88 (GPR88)X   
Class A OrphanGPR31G-protein coupled receptor 31 (GPR31)X   
Class A OrphanGPR32G-protein coupled receptor 32 (GPR32)X   
Class A OrphanGPR35G-protein coupled receptor 35 (GPR35)XX X
Class A OrphanGPR37Endothelin B receptor-like (EDNRBL)X   
Class A OrphanGPR37L1G protein-coupled receptor 37 like 1 (GPR37L1)X   
Class A OrphanGPR39G-protein coupled receptor 39 (GPR39)X X 
Class A OrphanGPR4G-protein coupled receptor 4 (GPR4)X   
Class A OrphanGPR45G-protein coupled receptor 45 (GPR45)X   
Class A OrphanGPR50G-protein coupled receptor 50 (GPR50)X   
Class A OrphanGPR52G-protein coupled receptor 52 (GPR52)X   
Class A OrphanGPR55G protein-coupled receptor 55 (GPR55)X   
Class A OrphanGPR6G-protein coupled receptor 6 (GPR6)X   
Class A OrphanGPR61G-protein coupled receptor 61 (GPR61)X   
Class A OrphanGPR65G-protein coupled receptor 65 (GPR65)X   
Class A OrphanGPR75G-protein coupled receptor 75 (GPR75)X   
Class A OrphanGPR78G-protein coupled receptor 78 (GPR78)X   
Class A OrphanGPR79G protein-coupled receptor 79 pseudogene (GPR79)X   
Class A OrphanOXGR1Oxoglutarate (alpha-ketoglutarate) receptor 1 (OXGR1)X X 
Class A OrphanP2RY8Purinergic receptor P2Y, G-protein coupled, 8 (P2RY8)X   
Class A OrphanTAAR5Trace amine associated receptor 5 (TAAR5)X   
Class A OrphanrGPR35G-protein coupled receptor 35 (rGPR35)X   
Class B OrphanGPR97G-protein coupled receptor 97 (GPR97)X   
Class B OrphanGPR123G-protein coupled receptor 123 (GPR123)X   
Class B OrphanGPR157G-protein coupled receptor 157 (GPR157)X   
Class B OrphanBAI1Brain-specific angiogenesis inhibitor 1 (BAI1)X   
Class B OrphanBAI2Brain-specific angiogenesis inhibitor 2 (BAI2)X   
Class B OrphanBAI3Brain-specific angiogenesis inhibitor 3 (BAI3)X   
Complement peptideC3AR1Complement component 3a receptor 1 (C3A)X   
Complement peptideC5AR1Complement component 5a receptor 1 (C5A)XX X
Complement peptideC5L2G-Protein Coupled Receptor 77 (C5L2)X  X
Complement peptidemC5AR1Complement component 5a receptor 1 (mC5AR)X   
Corticotropin-releasing factormCRHR1Corticotropin releasing hormone receptor 1 (mCRF1)X   
Corticotropin-releasing factorCRHR1Corticotropin releasing hormone receptor 1 (CRF1)XX X
Corticotropin-releasing factorCRHR2Corticotropin releasing hormone receptor 2 (CRF2)XX X
DopamineDRD1Dopamine receptor D1 (D1)XX X
DopamineDRD2LDopamine Receptor D2 (long isoform) (D2L)XX  
DopamineDRD2SDopamine Receptor D2 (short isoform) (D2S)XX  
DopamineDRD3Dopamine Receptor D3 (D3)X   
DopamineDRD4Dopamine Receptor D4 (D4)XX  
DopamineDRD5Dopamine receptor D5 (D5)XX  
DopaminemDRD5Dopamine receptor D5 (mDRD5)X   
DopaminerDRD1Dopamine receptor D1 (rD1)X   
DopaminerDRD2LDopamine Receptor D2 (long isoform) (rD2L)X   
DopaminerDRD2SDopamine Receptor D2 (short isoform) (rD2S)X   
EndothelinmEDNRAEndothelin receptor type A (mETA)X   
EndothelinmEDNRBEndothelin receptor type B (mETB)X   
EndothelinEDNRAEndothelin receptor type A (ETA)X X 
EndothelinEDNRBEndothelin receptor type B (ETB)X  X
Estrogen (G protein coupled) receptorGPR30G protein-coupled estrogen receptor 1 (GPER)X   
FormylpeptideFPR1Formylpeptide receptor 1 (FPR1)XX X
FormylpeptideFPR3Formyl peptide receptor 3 (FPRL2) X  
FormylpeptideFPRL1Formylpeptide receptor-like 1 (FPR2/ALX)XX X
Formylpeptide mFPR1Formylpeptide receptor 1 (mFPR1)X   
FormylpeptidemFPR2Formylpeptide receptor 2 (FPR2)X   
Free Fatty AcidmFFAR1Free fatty acid receptor 1 (FFA1)X   
Free Fatty AcidFFAR1Free fatty acid receptor 1 (FFA1)X X 
Free Fatty AcidFFAR2Free fatty acid receptor 2 (GPR43)  X 
Free Fatty AcidFFAR3Free fatty acid receptor 3 (GPR41) X  
Free fatty acidGPR120G-protein coupled receptor 120, long isoform (FFA4)X  X
Free fatty acidGPR120SG-protein Coupled Receptor 120, short isoform (FFA4)X   
Free fatty acidcyno GPR120G-protein coupled receptor 120 (FFA4)X   
Free Fatty AcidrFFAR1Free fatty acid receptor 1 (FFA1)X   
Free fatty acidrGPR120G-protein coupled receptor 120 (FFA4)X   
GABABGABBR1-GABBR2gamma-aminobutyric acid (GABA) B receptor, 1 (GABB1) X  
GalaninGALR1Galanin receptor 1 (GALR1)XX X
GalaninGALR2Galanin receptor 2 (GALR2)X X 
GalaninmGALR2Galanin Receptor 2 (mGALR2)X   
GhrelinmGHSRGhrelin receptor (ghrelin)X   
GhrelinGHSRGhrelin receptor (ghrelin)X X 
GlucagonGCGRGlucagon receptor (glucagon)XX X
GlucagonGHRHRGrowth hormone releasing hormone receptor (GHRH) X  
GlucagonGIPRGastric inhibitory polypeptide receptor (GIP)XX  
GlucagonGLP1RGlucagon-like peptide receptor 1 (GLP-1)XX X
GlucagonGLP2RGlucagon-like peptide receptor 2 (GLP-2)XX X
GlucagonmGIPRGastric inhibitory polypeptide receptor (mGIP)X   
GlucagonmGLP1RGlucagon-like peptide receptor 1 (mGLP-1)X   
GlucagonmGCGRGlucagon Receptor (glucagon)X   
GlucagonSCTRSecretin receptor (secretin)XX X
Glycoprotein hormone receptorTSHR(L)Thyroid Stimulating Hormone Receptor (TSH)XX  
Glycoprotein hormone receptorLHCGRChoriogonadotropin receptor (LH)XX  
Glycoprotein hormone receptorFSHRFollicle stimulating hormone receptor (FSHR)XX  
Gonadotropin-releasing hormoneGNRHRGonadotropin-releasing hormone receptor (GnRH)  X 
HistamineHRH1Histamine receptor H1 (H1)X X 
HistamineHRH2Histamine receptor H2 (H2)XXX 
HistamineHRH3Histamine receptor H3 (H3)XX  
HistamineHRH4Histamine receptor H4 (H4)X   
Hydroxycarboxylic acidGPR81Hydroxycarboxylic acid receptor 1 (HCA1) X  
Hydroxycarboxylic acidGPR109AHydroxycarboxylic acid receptor 2 (HCA2)XX  
Hydroxycarboxylic acidGPR109BHydroxycarboxylic acid receptor 3 (HCA3)XX  
Kisspeptin receptorKISS1RKISS1-derived peptide receptor (kisspeptin)X   
LeukotrieneLTB4RLeukotriene B4 receptor (BLT1)XXXX
LeukotrienemLTB4RLeukotriene B4 receptor (mBLT1)X   
Leukotriene CYSLTR2Cysteinyl leukotriene receptor 2 (CYSLT2)  X 
LeukotrieneOXER1Oxoeicosanoid (OXE) receptor 1 (OXE)XX X
Lysophospholipid (LPA)EDG7Lysophosphatidic acid receptor 3 (LPA3)X XX
Lysophospholipid (LPA)EDG2Lysophosphatidic acid receptor 1 (LPA1)  XX
Lysophospholipid (LPA)EDG4Lysophosphatidic acid receptor 2 (LPA2)X X 
Lysophospholipid (LPA)GPR92Lysophosphatidic acid receptor 5 (GPR92)X X 
Lysophospholipid (S1P)mEDG1Sphingosine 1-phosphate receptor 1 (mS1P1)X   
Lysophospholipid (S1P)mEDG3Sphingosine 1-phosphate receptor 3 (S1P3)X   
Lysophospholipid (S1P)mEDG5Sphingosine 1-phosphate receptor 2 (mS1P2)X   
Lysophospholipid (S1P)EDG5Sphingosine 1-phosphate receptor 2 (S1P2)X  X
Lysophospholipid (S1P)EDG6Sphingosine 1-phosphate receptor 4 (S1P4)X   
Lysophospholipid (S1P)EDG3Sphingosine 1-phosphate receptor 3 (S1P3)X XX
Lysophospholipid (S1P)EDG1Sphingosine 1-phosphate receptor 1 (S1P1)XX X
Lysophospholipid (S1P)cEDG5Sphingosine 1-phosphate receptor 2 (cS1P2)X   
Lysophospholipid (S1P)sEDG5Sphingosine 1-phosphate receptor 2 (sS1P2)X   
Lysophospholipid (S1P)rEDG5Sphingosine 1-phosphate receptor 2 (rS1P2)X   
Melanin-concentrating hormonemMCHR1Melanin concentrating hormone receptor 1 (MCH1)X   
Melanin-concentrating hormone MCHR1Melanin concentrating hormone receptor 1 (MCH1)XX X
Melanin-concentrating hormone MCHR2Melanin-concentrating hormone receptor 2 (MCH2)X X 
MelanocortinMC5RMelanocortin receptor 5 (MC5)XX  
MelanocortinMC1RMelanocortin receptor 1 (MC1)XX  
MelanocortinMC3RMelanocortin receptor 3 (MC3)XX X
MelanocortinMC4RMelanocortin receptor 4 (MC4)XX  
MelatoninMTNR1AMelatonin receptor 1A (MT1)XX X
MelatoninMTNR1BMelatonin receptor 1B (MT2)XX X
Metabotropic glutamateGRM1Metabotropic glutamate receptor 1 (mGlu1)  X 
Metabotropic glutamateGRM2Metabotropic glutamate receptor 2 (mGlu2) X  
Metabotropic glutamateGRM3Metabotropic glutamate receptor 3 (MGlu3) X  
Metabotropic glutamateGRM4Metabotropic glutamate receptor 4 (mGlu4) X  
Metabotropic glutamateGRM5Metabotropic glutamate receptor 5 (mGlu5)  X 
Metabotropic glutamateGRM6Metabotropic glutamate receptor 6 (mGlu6) X  
MotilinMLNRMotilin receptor (motilin)X XX
Neuromedin UNMU1RNeuromedin U receptor 1 (NMU1)X XX
Neuropeptide B & WNPBWR1Neuropeptides B/W receptor 1 (NPBW1)XX  
Neuropeptide B & WNPBWR2Neuropeptides B/W receptor 2 (NPBW2)XX  
Neuropeptide FF & AFNPFFR1Neuropeptide FF receptor 1 (NPFF1)XX  
Neuropeptide SNPSR1bneuropeptide S receptor 1 (NPS receptor)X   
Neuropeptide YNPY1RNeuropeptide Y receptor Y1 (Y1)X   
Neuropeptide YNPY2RNeuropeptide Y receptor Y2 (Y2)XXXX
Neuropeptide YmPPYR1Pancreatic polypeptide receptor 1 (Y4)X   
Neuropeptide YmNPY1RNeuropeptide Y1 receptor (Y1)X   
Neuropeptide YmNPY2RNeuropeptide Y2 receptor (NPY2R)X   
Neuropeptide YPPYR1Pancreatic polypeptide receptor 1 (Y4)XX  
NeurotensinNTSR1Neurotensin receptor 1 (NTS1)X XX
OpioidOPRD1Opioid receptor delta (δ)XX X
OpioidOPRK1Opioid receptor kappa (κ)XX X
OpioidOPRL1Opioid receptor-like receptor (NOP)XX X
OpioidOPRM1Opioid receptor mu (μ)XX X
OpioidmOPRD1Opioid receptor delta (δ (murine))X   
OpioidmOPRK1Opioid receptor kappa (κ (murine))X   
OpioidmOPRM1Opioid receptor mu (μ (murine))X   
OpioidrOPRM1Opioid receptor mu (μ)X   
OrexinHCRTR1Orexin receptor 1 (OX1)X XX
OrexinHCRTR2Orexin receptor 2 (OX2)X XX
Other 7TM proteinsGPR137G-protein coupled receptor 137B (TM7SF1)X   
Other 7TM proteinsGPR107G-protein coupled receptor 107 (GPR107)X   
Other 7TM proteinsGPR143G-protein coupled receptor 143 (GPR143)X   
P2YP2RY1Purinergic receptor P2Y, G-protein coupled, 1 (P2RY1)X XX
P2YP2RY11Purinergic receptor P2Y, G-protein coupled, 11 (P2Y11)X   
P2YP2RY12Purinergic receptor P2Y, G-protein coupled, 12 (P2Y12)X  X
P2YP2RY2Purinergic receptor P2Y, G-protein coupled, 2 (P2Y2)X XX
P2YP2RY4Pyrimidinergic receptor P2Y, G-protein coupled, 4 (P2Y4)X  X
P2YP2RY6Pyrimidinergic receptor P2Y, G-protein coupled, 6 (P2Y6)X   
P2YmP2RY12P2Y Purinoceptor 12 (mP2Y12)X   
P2YmP2RY6P2Y Purinoceptor 6 (P2Y6)X   
Parathyroid hormonePTHR1Parathyroid hormone receptor 1 (PTH1)XXXX
Parathyroid hormonePTHR2Parathyroid hormone receptor 2 (PTH2)XXXX
Peptide P518GPR103pyroglutamylated RFamide peptide receptor (QRFPR)X X 
Platelet-activating factor mPTAFRPlatelet-activating factor receptor (mPAF)X   
Platelet-activating factorPTAFRPlatelet activating receptor (PAF)X XX
ProkineticinPROKR1Prokineticin receptor 1 (PKR1)XXXX
ProkineticinPROKR2Prokineticin receptor 2 (PKR2)X  X
ProkineticinrPROKR1Prokineticin receptor 1 (rPROKR1)X   
ProkineticinrPROKR2Prokineticin receptor 2 (rPKR2)X   
Prolactin releasing peptide receptorPRLHRProlactin releasing hormone receptor (PRRP)X XX
ProstanoidPTGDRProstaglandin D2 receptor (DP1) X  
ProstanoidPTGER1Prostaglandin E receptor 1 (subtype EP1) (EP1)X X 
ProstanoidPTGER2Prostaglandin E receptor 2 (subtype EP2) (EP2)XX  
ProstanoidPTGER3Prostaglandin E receptor 3 (subtype EP3) (EP3)XXX 
ProstanoidPTGER4Prostaglandin E receptor 4 (subtype EP4) (EP4)X  X
ProstanoidPTGFRProstaglandin F receptor (FP) (FP)X XX
ProstanoidPTGIRProstaglandin I2 (prostacyclin) receptor (IP) (IP1)XX X
ProstanoidrPTGER4Prostaglandin E receptor 4 (subtype EP4), rat (rEP4)X   
ProstanoidrCRTH2Prostanoid DP2 receptor (rGPR44)X   
ProstanoidTBXA2RThromboxane A2 receptor (TP)X XX
ProstanoidmPTGER4Prostaglandin E receptor 4 (subtype EP4) (EP4)X   
ProstanoidmCRTH2Prostanoid DP2 receptor (mDP2)X   
ProstanoidCRTH2prostaglandin D2 receptor 2 (PTGDR2)XX  
Protease activatedF2RCoagulation factor II (thrombin) receptor (PAR1)X   
Protease activatedF2RL1Coagulation factor II (thrombin) receptor-like 1 (PAR2) (PAR2)X XX
Protease activatedF2RL3Coagulation factor II (thrombin) receptor-like 3 (PAR4) (PAR4)X XX
RelaxinmRXFP3Relaxin family peptide receptor 3 (RXFP3)X   
RelaxinmRXFP4Relaxin family peptide receptor 4 (RXFP4)X   
RelaxinRXFP1Relaxin family peptide receptor 1 (RXFP1) X  
RelaxinRXFP2Relaxin family peptide receptor 2 (RXFP2) X  
RelaxinRXFP3Relaxin family peptide receptor 3 (RXFP3)XX X
RelaxinRXFP4Relaxin family peptide receptor 4 (RXFP4)XX  
SomatostatinSSTR1Somatostatin receptor 1 (SST1)X   
SomatostatinSSTR2Somatostatin receptor 2 (SST2)XX X
SomatostatinSSTR3Somatostatin receptor 3 (SST3)XX  
SomatostatinSSTR4Somatostatin receptor 4 (SST4)XX  
SomatostatinSSTR5Somatostatin receptor 5 (SST5)XX  
SomatostatinmSSTR2Somatostatin receptor 2 (mSST2)X   
SomatostatinmSSTR5Somatostatin receptor 5 (mSRIF1B)X   
TachykininTACR1Tachykinin receptor 1 (NK1)X XX
TachykininTACR2Tachykinin receptor 2 (NK2)X XX
TachykininTACR3Tachykinin receptor 3 (NK3)XXXX
Thyrotropin releasing hormoneTRHRThyrotropin-releasing hormone receptor (TRH1)X XX
Trace amineTAAR1trace amine associated receptor 1 (TA1) X  
UrotensinUTR2Urotensin II receptor (UT)X XX
UrotensinmUTR2Urotensin II receptor (mUT)X   
Vasopressin and OxytocinmOXTROxytocin recepter (OT)X   
Vasopressin and OxytocinAVPR1AVasopressin receptor 1A (V1A)X XX
Vasopressin and OxytocinAVPR1BVasopressin receptor 1B (V1B)X XX
Vasopressin and OxytocinAVPR2Vasopressin receptor 2 (V2)XX X
Vasopressin and OxytocinOXTROxytocin Receptor (OT)X XX
VIP and PACAPrVIPR1Vasoactive intestinal peptide receptor 1 (rVPAC1)X   
VIP and PACAPVIPR1Vasoactive intestinal peptide receptor 1 (VPAC1)XXXX
VIP and PACAPVIPR2Vasoactive intestinal peptide receptor 2 (VPAC2)XXXX
VIP and PACAPADCYAP1R1Adenylate cyclase activating polypeptide receptor 1 (PAC1)XXXX
VIP and PACAPmVIPR1Vasoactive intestinal peptide receptor 1 (mVPAC1)X   
VIP and PACAPmADCYAP1R1Adenylate Cyclase Activating Polypeptide 1 Receptor 1 (mPAC1)X   

Overview of GPCRscan® Panels & Services

Services Assays Pre-configured Panel Customizable? Single Assay
Technology		  Turnaround Times*
gpcrMAX 168 Yes No Yes 4 weeks
orphanMAX 73 Yes No Yes 4 weeks
gpcrELECT 1-600 No Yes Multiple 15 business days
gpcrE/IC50ELECT 1-600 No Yes Multiple 15 business days
gpcrBIAS (New) >150 No Yes Multiple 6 weeks
gpcrTRIO >70 No Yes Multiple 4 weeks
gpcrDUO Inquire No Yes Multiple 4 weeks
gpcrPANELS Varies Yes No Yes 6 weeks
*For gpcrMAX, orphanMAX and gpcrPANELs, turnaround time is calculated based on fixed start date of the panel run.  Although standard turnaround times are 4 weeks, express turnaround times of 10 days can also be requested.

gpcrMAX

168 assays – industry leading functional cell-based GPCR panel
The most comprehensive panel of naturally coupled, functional cell-based assays for known GPCRs utilizing the proven G-protein independent PathHunter® Arrestin technology.
+

orphanMAX

73 assays – largest orphan GPCR assay panel available
Industry leading panel of naturally coupled, functional cell-based assays for Class A and Class B orphan GPCRs utilizing the proven G-protein independent PathHunter® Arrestin technology.
+

gpcrELECT

A flexible approach to personalized screening
Select from our broad collection of over 600 human and ortholog cell-based GPCR assays available in multiple direct functional readouts.Create a customized assay panel of any size comprised only of the GPCRs and assay readouts relevant to your programs.
+

gpcrE/IC50ELECT

Quantitative binding affinity of compound-GPCR interactions
Quantitative affinity measurements determined in agonist, antagonist or allosteric modulator modes. Calculations are based on a 10-point dose-response curve, performed in duplicate and can be determined for any GPCR/compound combination.
+

gpcrBIAS

gpcrBIAS Functional Selectivity Indexing Service
Quantify ligand bias by selecting from our broad portfolio of over 150 cell based GPCR assays available in multiple direct functional readouts.
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gpcrDUO

Compound mode of action studies using human & ortholog assays
Study the mode of action of your compound by selecting any pair of human and non-human (mouse/rat/canine) assays or choose any two assay readouts (Arrestin, cAMP, Calcium, Internalization) for the same GPCR target to elucidate novel compound activity.
+

gpcrTRIO

Multi-pathway analysis using 3 independent assay readouts
An ideal tool to investigate how GPCR receptor activation or desensitization determines novel compound activity.  Select any three assay readouts (Arrestin, cAMP, Calcium, Internalization) for the same GPCR target to uncover a complete activity profile on your lead compound.
+

gpcrPANELS

13 therapeutically relevant disease panels
Broadly screen for new leads or profile compounds of interest against a collection of therapeutically focused targets organized by disease area.  Panels include 13 Therapeutic and 1 family-specific Chemokine Panel.  Panels are organized based on current scientific understanding and are updated regularly.
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Assay Comparision Matrix Tool

Columns may be sorted by selecting panel name (column) to compare assay membership for each GPCRscan® assay panel.
TargetName ▲gpcrMAXAssaysorphanMAXAssaysgpcrELECTAssasysgpcrEIC50ELECTAssaysgpcrBIASAssaysgpcrDUOTRIOAssays
ADCYAP1R1X XXXX
ADORA1  XXXX
ADORA2A  XX  
ADORA2B  XX  
ADORA3X XXXX
ADRA1A  XX  
ADRA1BX XXXX
ADRA1D(82-572)  XX  
ADRA2AX XXXX
ADRA2BX XX  
ADRA2CX XXXX
ADRB1X XXXX
ADRB2X XXXX
ADRB2(W158A)      
ADRB3  XX  
AGTR1X XXXX
AGTRL1X XXXX
AVPR1AX XXXX
AVPR1BX XXXX
AVPR2X XXXX
AVPR2(S167T)      
BAI1 XXX  
BAI2 XXX  
BAI3 XXX  
BDKRB1X XXXX
BDKRB2X XXXX
BRS3X XXXX
C3AR1  XX  
C5AR1X XXXX
C5L2X XXXX
CALCRX XXXX
CALCRL-RAMP1X XXXX
CALCRL-RAMP2X XX  
CALCRL-RAMP3X XXXX
CALCR-RAMP2X XX  
CALCR-RAMP3X XXXX
CASR  XX  
CCKARX XXXX
CCKBRX XXXX
CCR1X XXXX
CCR10X XXXX
CCR2X XXXX
CCR3X XX  
CCR4X XXXX
CCR5X XXXX
CCR6X XXXX
CCR7X XXXX
CCR8X XX  
CCR9X XX  
CCRL1  XX  
CCRL2 XXX  
cEDG5  XX  
cGPR91      
CHRM1X XXXX
CHRM2X XXXX
CHRM3X XXXX
CHRM4X XXXX
CHRM5X XXXX
CMKLR1X XXXX
CNR1X XXXX
CNR2X XXXX
CRHR1X XXXX
CRHR2X XXXX
CRTH2X XXXX
CX3CR1X XX  
CXCR1X XXXX
CXCR2X XXXX
CXCR3X XXXX
CXCR4X XXXX
CXCR5X XXXX
CXCR6  XX  
CXCR7X XXXX
cyno CXCR1  XX  
cyno CXCR2  XX  
cyno GPR120  XX  
cyno MRGPRX2  X   
CYSLTR2  XX  
DARC XXX  
DRD1X XXXX
DRD2LX XXXX
DRD2SX XXXX
DRD3X XX  
DRD4X XXXX
DRD5X XXXX
EBI2X XXXX
EDG1X XXXX
EDG2  XXXX
EDG3X XXXX
EDG4X XXXX
EDG5X XXXX
EDG6X XX  
EDG7X XXXX
EDNRAX XXXX
EDNRBX XXXX
F2RX XX  
F2RL1X XXXX
F2RL3X XXXX
FFAR1X XXXX
FFAR2  XX  
FFAR3  XX  
FPR1X XXXX
FPR3  XX  
FPRL1X XXXX
FSHRX XXXX
GABBR1-GABBR2  XX  
GALR1X XXXX
GALR2X XXXX
GCGRX XXXX
GHRHR  XX  
GHSRX XXXX
GHSR1b XXX  
GIPRX XXXX
GLP1RX XXXX
GLP2RX XXXX
GNRHR  XX  
GPBAR1  XXXX
GPR1X XXXX
GPR101 XXX  
GPR103X XXXX
GPR107 XXX  
GPR109AX XXXX
GPR109BX XXXX
GPR119X XX  
GPR12 XXX  
GPR120X XXXX
GPR120S  XX  
GPR123 XXX  
GPR132 XXX  
GPR135 XXX  
GPR137 XXX  
GPR139 XXX  
GPR141 XXX  
GPR142 XXX  
GPR143 XXX  
GPR146 XXX  
GPR148 XXX  
GPR149 XXX  
GPR15 XXX  
GPR150 XXX  
GPR151 XXX  
GPR152 XXX  
GPR157 XXX  
GPR161 XXX  
GPR162 XXX  
GPR17 XXX  
GPR171 XXX  
GPR173 XXX  
GPR176 XXX  
GPR18 XXX  
GPR182 XXX  
GPR20 XXX  
GPR22 XXX  
GPR23 XXX  
GPR25 XXX  
GPR26 XXX  
GPR27 XXX  
GPR3 XXX  
GPR30 XXX  
GPR31 XXX  
GPR32 XXX  
GPR35X XXXX
GPR37 XXX  
GPR37L1 XXX  
GPR39 XXX  
GPR4 XXX  
GPR45 XXX  
GPR50 XXX  
GPR52 XXX  
GPR55 XXX  
GPR6 XXX  
GPR61 XXX  
GPR65 XXX  
GPR75 XXX  
GPR78 XXX  
GPR79 XXX  
GPR81  XX  
GPR83 XXX  
GPR84 XXX  
GPR85 XXX  
GPR88 XXX  
GPR92X XXXX
GPR97 XXX  
GRM1  XX  
GRM2  XX  
GRM3  XX  
GRM4  XX  
GRM5  XX  
GRM6  XX  
GRPRX XXXX
HCRTR1X XXXX
HCRTR2X XXXX
HRH1X XXXX
HRH2X XXXX
HRH3X XXXX
HRH4X XX  
HTR1AX XXXX
HTR1BX XXXX
HTR1EX XX  
HTR1FX XXXX
HTR2AX XXXX
HTR2B  XX  
HTR2CX XXXX
HTR2C(VGV)  XX  
HTR2C(VNV)  XX  
HTR2C(VSV)  XX  
HTR5AX XXXX
HTR6  XX  
HTR7A      
HTR7B      
HTR7D  XX  
KISS1RX XX  
LGR4 XXX  
LGR5 XXX  
LGR6 XXX  
LHCGRX XXXX
LTB4RX XXXX
mADCYAP1R1  XX  
mADORA2B  XX  
mADORA3  XX  
mADRA1B      
mAGTRL1  XX  
mAVPR2      
mBRS3      
MC1RX XXXX
MC3RX XXXX
MC4RX XXXX
MC4R(T162I)      
mC5AR1  XX  
MC5RX XXXX
mCCKAR      
mCCR1  XX  
mCCR2  XX  
mCCR3  XX  
mCCR4  XX  
mCCR5  XX  
mCCR6  XX  
mCCR7  XX  
mCCR8  XX  
mCCR9  XX  
MCHR1X XXXX
MCHR2X XXXX
mCMKLR1  XX  
mCNR1  XX  
mCNR2  XX  
mCRHR1  XX  
mCRTH2  XX  
mCX3CR1  XX  
mCXCR2  XX  
mCXCR3  XX  
mCXCR4  XX  
mCXCR5  XX  
mCXCR6  XX  
mCXCR7  XX  
mDRD5  XX  
mEBI2  XX  
mEDG1  XX  
mEDG3  XX  
mEDG5  XX  
mEDNRA  XX  
mEDNRB  XX  
mF2RL1      
mFFAR1  XX  
mFPR1  XX  
mFPR2  XX  
mGALR1      
mGALR2  XX  
mGCGR  XX  
mGHSR  XX  
mGIPR  XX  
mGLP1R  XX  
mGLP1R-ADCY2      
mGPR1  XX  
mGPR120  XX  
mGPR84  XX  
mHCRTR1      
mHTR2A  XX  
mHTR2C  XX  
MLNRX XXXX
mLTB4R  XX  
mMC3R      
mMC4R      
mMC5R      
mMCHR1  XX  
mNPY1R  XX  
mNPY2R  XX  
mOPRD1  XX  
mOPRK1  XX  
mOPRM1  XX  
mOXTR  XX  
mP2RY12  XX  
mP2RY6  XX  
mPPYR1  XX  
mPTAFR  XX  
mPTGER4  XX  
mPTGIR      
MRGPRD XXX  
MRGPRE XXX  
MRGPRF XXX  
MRGPRX1X XXXX
MRGPRX2X XXXX
MRGPRX4 XXX  
mRHO(P23H)      
mRXFP1      
mRXFP3  XX  
mRXFP4  XX  
mSSTR2  XX  
mSSTR5  XX  
mTAAR1      
mTACR1      
MTNR1AX XXXX
MTNR1B  XXXX
mUTR2  XX  
mVIPR1  XX  
NMBRX XXXX
NMU1RX XXXX
NPBWR1X XXXX
NPBWR2X XXXX
NPFFR1X XXXX
NPSR1bX XX  
NPY1RX XX  
NPY2RX XXXX
NTSR1X XXXX
OPN5 XXX  
OPRD1X XXXX
OPRK1X XXXX
OPRL1X XXXX
OPRM1X XXXX
OXER1X XXXX
OXGR1 XXX  
OXTRX XXXX
P2RY1X XXXX
P2RY11X XXXX
P2RY12X XX  
P2RY2X XXXX
P2RY4X XXXX
P2RY6X XX  
P2RY8 XXX  
PPYR1X XXXX
PRLHRX XXXX
PROKR1X XXXX
PROKR2X XXXX
PTAFRX XXXX
PTGDR  XX  
PTGER1  XX  
PTGER2X XX  
PTGER3X XXXX
PTGER4X XXXX
PTGFRX XXXX
PTGIRX XXXX
PTHR1X XXXX
PTHR2X XXXX
rCHRM4  XX  
rCNR2  XX  
rCRTH2  XX  
rDRD1  XX  
rDRD2L  XX  
rDRD2S  XX  
rEDG5  XX  
rFFAR1  XX  
rGPR120  XX  
rGPR35  XX  
rHTR2C  XX  
rOPRM1  XX  
rPROKR1  XX  
rPROKR2  XX  
rPTGER4  XX  
rTAAR1      
rVIPR1  XX  
RXFP1  XX  
RXFP2  XX  
RXFP3X XXXX
RXFP4  XXXX
SCTRX XXXX
sEDG5  XX  
SMO(W535L)      
SSTR1X XX  
SSTR2X XXXX
SSTR3X XXXX
SSTR4  XXXX
SSTR5X XXXX
TAAR1  XX  
TAAR5 XXX  
TACR1X XXXX
TACR2X XXXX
TACR3X XXXX
TBXA2RX XXXX
TRHRX XXXX
TSHR(L)X XXXX
UTR2X XXXX
VIPR1X XXXX
VIPR2X XXXX
XCR1      

Panel Highlights and Benefits

  • Comprehensive menu of >600 functional, non-force coupled GPCR assays
  • Multiple functional readouts including Arrestin Recruitment, cAMP, Calcium and Internalization
  • Proven and trusted technology platform
  • Flexible panel size - pre-defined panels or personalized assay selection
  • Functional data - Accurate, precise and reproducible
  • Rapid turnaround time
 

Arrestin

2nd Messenger

Internalization

  
 
How it Works
How it Works
How it Works
  

To ensure your compounds are included in the Test Date of your choosing, submit your compounds and PO by the date indicated in the "Compounds & PO Due" column below.

2020 gpcrMAX and orphanMAX Panel Run Schedule

Panel Test Dates Compounds & PO Due Report & Invoicing
gpcrMAX,
orphanMAX		 January 28 January 24 February 25
March 10 March 6 April 7
April 21 April 17 May 19
June 2 May 29 June 30
July 14 July 10 August 11
August 25 August 21 September 22
October 6 October 2 November 3
November 17 November 13 December 22
 

2020 nhrMAX Panel Run Schedule

Panel Test Dates Compounds & PO Due Report & Invoicing

nhrMAX

 February 11 February 7 March 10
March 24 March 20 April 21
May 5 May 1 June 2
June 16 June 12 July 14
July 28 July 24 August 25
September 8 September 4 October 6
October 20 October 16 November 17