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TKscan℠ - Cell-Based Tyrosine Kinase Panel

LeadHunter℠ Discovery Services offers a rapidly growing portfolio of cell-based kinase assays for detection of both Receptor Tyrosine Kinase (RTK) and Cytosolic Tyrosine Kinase (CTK) signaling. Our panel of over 30 kinase targets provides you a comprehensive understanding of compound binding within the tyrosine kinase family and allows you to test your compounds in a more physiological setting to determine inhibitor membrane permeability, competition in the presence of native ATP levels and effects under more physiologic conditions so you can make more informed decisions about the therapeutic potential and off-target liabilities of your compounds.

Comprehensive Menu

Powered by the PathHunter® technology, our comprehensive menu of receptor tyrosine kinase and cytosolic tyrosine kinase assays is designed for compound screening and profiling against high value kinase targets in the areas of oncology, neurological disorders, metabolic disease and inflammation. These fully optimized, target-validated assays allow you to study kinase activation, receptor internalization or screen for novel kinase inhibitors using a simple and quantitative chemiluminescent assay.

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Panel Highlights and Benefit

  • Full length human kinases expressed in cells
  • High quality, functional data – accurate, precise and reproducible
  • Flexible service options – either pre-defined panels or personalized assay selection
  • Broad applications – primary screening, lead optimization and mechanism of action studies
  • Agonist and antagonist modes available
  • Rapid data turnaround time
 How it Works

Overview of TKscan℠ Panels & Services

Services Assays Pre-configured Panel Customizable? Standard Turnaround
tkMAX 25 Yes No 6 weeks
tkELECT 1-64 No Yes 4 weeks
tkE/IC50ELECT 1-64 No Yes 4 weeks

tkMAX

25 assays – growing functional cell-based tyrosine kinase panel
Industry leading panel of functional cell-based assays including both receptor tyrosine kinases (RTKs) and cytosolic tyrosine kinases (CTKs).
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tkELECT

A flexible approach to personalized screening
A flexible approach to personalized GPCR screening and profiling.  Select from our expanding menu of 34 RTK and CTK assays. Choose only the target you need.  An ideal solution for any size compound collection.
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tkE/IC50ELECT

Quantitative binding affinity of compound-kinase interactions
Quantitative affinity measurements for any kinase/compound combination. Calculations are based on a 10-point dose-response curve, performed in duplicate. Measurements are made under optimized conditions to generate consistent and reproducible data that reliably reflects the drug's potency.
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TKscan℠ Kinase Assay List

Below is a complete list of available Receptor and Cytosolic Tyrosine Kinase assays available in the TKscan℠ panel.  List may be sorted by "Target Gene", "Common Name", "Gene Symbol", "Accession No." or "Species.

Receptor Tyrosine Kinase Assays

Gene Symbol ▲Common NameEntrez Gene Symbol
AXLAXL receptor tyrosine kinase (AXL)AXL
cINSRaInsulin receptor, isoform A (INSR)cINSRa
cINSRbInsulin receptor, isoform B (INSR)cINSRb
c-KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT)c-KIT
c-Ret-GFRα1Proto-oncogene tyrosine-protein kinase receptor Ret (RET)c-Ret-GFRα1
c-Ret-GFRα2Proto-oncogene tyrosine-protein kinase receptor Ret (RET)c-Ret-GFRα2
DDR1Discoidin domain receptor 1 (CD167a)DDR1
EGFR/ErbB3Epidermal growth factor receptorEGFR
EphA4EPH receptor A4 (EphA4)EphA4
EphA5Ephrin type-A receptor 5 (EphA5)EphA5
EphA7Ephrin type-A receptor 7 (EphA7)EphA7
EphB1Ephrin type-B receptor 1 (EphB1)EphB1
EphB2Ephrin type-B receptor 2 (EphB2)EphB2
EphB3Ephrin type-B receptor 3 (EphB3)EphB3
EphB4Ephrin type-B receptor 4 (EphB4)EphB4
ErbB1v-erb-b2 erythroblastic leukemia viral oncogene homolog 1 (EGFR)ErbB1
ErbB2-ErbB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (HER2)ErbB2-ErbB3
ErbB4erb-b2 receptor tyrosine kinase 4ErbB4
FGFR1Fibroblast growth factor receptor 1 (FGFR1)FGFR1
FGFR1-α-KlothoFibroblast Growth Factor Receptor 1 (FGFR1), α-KlothoFGFR1-α-Klotho
FGFR1-β-KlothoFibroblast growth factor receptor 1 (FGFR1), β-KlothoFGFR1-β-Klotho
FGFR2Fibroblast growth factor receptor 2 (FGFR2)FGFR2
FGFR4Fibroblast growth factor receptor 4 (FGFR4)FGFR4
FGFR4-α-KlothoFibroblast Growth Factor Receptor 4 (FGFR4), α-KlothoFGFR4-α-Klotho
FGFR4-β-KlothoFibroblast growth factor receptor 4 (FGFR4), β-KlothoFGFR4-β-Klotho
FLT4fms-related tyrosine kinase 4 (FLT4)FLT4
IGF1RInsulin-like growth factor 1 receptor (IGF1R)IGF1R
INSRaInsulin receptor, isoform A (INSR)INSRa
INSRbInsulin receptor, isoform B (INSR)INSRb
KDRKinase Insert Domain Receptor (VEGFR2)KDR
mINSRaInsulin receptor, isoform A (INSR)mINSRa
mINSRbInsulin receptor, isoform B (INSR)mINSRb
PDGFRaPlatelet-derived growth factor receptor alpha (PDGFRa)PDGFRa
PDGFRbPlatelet-derived growth factor receptor beta (PDGFRb)PDGFRB
rhTrkA-rhP75Neurotrophic tyrosine kinase receptor type 1 (NTRK1)rhTrkA-rhP75
rTrkA-rP75Neurotrophic tyrosine kinase receptor type 1 (NTRK1)rTrkA-rP75
Tie2Angiopoietin-1 receptor (Tie2)Tie2
TrkANeurotrophic tyrosine kinase receptor type 1 (NTRK1)TrkA
TrkA-P75Neurotrophic tyrosine kinase receptor type 1 (NTRK1)TrkA-P75
TrkBNeurotrophic tyrosine kinase receptor type 2 (NTRK2)TrkB
TrkB-P75Neurotrophic tyrosine kinase receptor type 2 (NTRK2)TrkB-P75
TrkCNeurotrophic tyrosine kinase receptor type 3 (NTRK3)TrkC
TrkC-P75Neurotrophic tyrosine kinase receptor type 3 (NTRK3)TrkC-P75

Cytosolic Tyrosine Kinase Assays

Gene Symbol ▲Common NameEntrez Gene Symbol
BLKB lymphoid tyrosine kinase (BLK)BLK
CSF3R-JAK1colony stimulating factor 3 receptor (CSF3R-JAK1)CSF3R-JAK1
EpoR-JAK2Erythropoietin receptor (EpoR)EpoR-JAK2
FGRFGR proto-oncogene, Src family tyrosine kinase (FGR)FGR
GHR-JAK1Growth hormone receptor (GHR-JAK1)GHR-JAK1
GHR-JAK2Growth hormone receptor (GHR-JAK2)GHR-JAK2
JAK3Janus kinase 3 (JAK3)JAK3
PRLR-JAK1Prolactin receptor (PRLR)PRLR-JAK1
PRLR-JAK2Prolactin receptor (PRLR)PRLR-JAK2
SYKSpleen tyrosine kinase (SYK)SYK
TYK2Tyrosine kinase 2 (TYK2)TYK2
YES1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 (YES)YES1

TKscan℠ Panels

Target ▲tkMAXtkELECTtkE/IC50ELECT
AXL XX
BLK XX
BTK XX
cINSRa XX
cINSRb XX
c-KITXXX
CLK1 XX
CLK2 XX
c-Ret-GFRα1 XX
c-Ret-GFRα2XXX
CSF1R XX
CSF3R-JAK1 XX
CSNK1D XX
DDR1XXX
EGFR/ErbB3 XX
EphA4 XX
EphA5XXX
EphA7XXX
EphB1 XX
EphB2XXX
EphB3XXX
EphB4XXX
ErbB1XXX
ErbB2-ErbB3XXX
ErbB4XXX
FGFR1 XX
FGFR1-α-Klotho XX
FGFR1-β-Klotho XX
FGFR2 XX
FGFR4 XX
FGFR4 XX
FGFR4-α-Klotho XX
FGFR4-β-Klotho XX
FGRXXX
FLT4XXX
GHR-JAK1 XX
GHR-JAK2 XX
HCK XX
IGF1RXXX
INSRa XX
INSRbXXX
JAK3XXX
KDRXXX
MEK1 XX
mINSRa XX
mINSRb XX
NIK   
PDGFRaXXX
PDGFRbXXX
PI3Kδ XX
PIM1 XX
PRLR-JAK1XXX
PRLR-JAK2XXX
PYK2 XX
rhTrkA-rhP75 XX
RIPK1 XX
RIPK1 XX
RIPK2 XX
RIPK3 XX
RIPK3 XX
rTrkA-rP75 XX
SIK1 XX
SYK XX
TIE2 XX
Tie2 XX
TrkA XX
TrkA-P75XXX
TrkB XX
TrkB-P75XXX
TrkC XX
TrkC-P75XXX
TYK2XXX
YES1 XX