Prostanoid DP2 receptor (mDP2)
- Target Class
- GPCR
- Family
- Prostanoid
- Official Symbol
- mCRTH2
- Species
- Mouse
- Accession Number
- NM_009962.2
- Alias Names
- DP2; CD294; Crth2; G protein-coupled receptor 44; G-protein coupled receptor 44; Grp45; PGD2 receptor; Ptgdr2; chemoattractant receptor-homologous molecule expressed on TH2 cells; prostaglandin D2 receptor 2; prostaglandin D2 receptor CRTH2; putative G-protein coupled receptor 44
- Background
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity).
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Solution Portfolio
Related Family Members:
Prostanoid
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| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Mouse |
93-0584C2 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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|
Available |
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