Targets / Kinase / BRK

protein tyrosine kinase 6 (BRK)

Target Class
Kinase
Family
TK
Official Symbol
PTK6
Entrez Gene ID
5753
Species
Human
Accession Number
NP_005966.1
Alias Names
BRK; PTK6 protein tyrosine kinase 6; breast tumor kinase; protein-tyrosine kinase 6; protein-tyrosine kinase BRK; tyrosine-protein kinase BRK
Background
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
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Related Group Members: TK
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