Targets / Kinase / BRSK2

BR serine/threonine kinase 2 (BRSK2)

Target Class
Kinase
Family
CAMK
Official Symbol
BRSK2
Entrez Gene ID
9024
Species
Human
Accession Number
EAX02438.1
Alias Names
BR serine/threonine kinase 2; BR serine/threonine-protein kinase 2; C11orf7; PEN11B; SAD1; STK29; brain-selective kinase 2; brain-specific serine/threonine-protein kinase 2; chromsosome 11 open reading frame 7; protein kinase SAD1B; serine/threonine-protein kinase 29; serine/threonine-protein kinase BRSK2; serine/threonine-protein kinase SAD-A
Background
Serine/threonine-protein kinase that plays a key role in polarization of neurons. Phosphorylates MAPT/TAU and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons.
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Solution Portfolio

Related Group Members: CAMK
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